Single-cell multi-omics technologies have revolutionized cancer research by allowing us to
examine individual cells at a molecular level. Unlike traditional bulk omics approaches …

Background The immune peptidome of OPSCC has not previously been studied. Cancer-
antigen specific vaccination may improve clinical outcome and efficacy of immune …

Motivation Interaction graphs are able to describe regulatory dependencies between
compounds without capturing dynamics. In contrast, mathematical models that are based on …

Systems biology investigates the understanding of complex biological processes, such as
ageing or cancer, by integrating a holistic view, which is mostly unconsidered when …

Pancreatic ductal adenocarcinomas (PDACs) are tumors with poor prognosis and limited
treatment options. Personalized medicine aims at characterizing actionable DNA variants by …

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of cancers
and patients have limited therapy options if primary treatment fails. Therefore, additional …

Boolean networks allow for the construction of dynamical models of biological processes
such as the cell cycle, cellular differentiation, ageing or diseases such as cancer. The …

Es gibt Hinweise, dass nichtvirale Tumor-Assoziierte Antigene (TAA) bei
Plattenepithelkarzinomen im Kopf-Hals Bereich (HNSCC) in Abhängigkeit der Tumorgenese …

2 klassischen Einteilungskriterien wie Größe des Primärtumors (T-Status),
Lymphknotenstatus (N-Status) und Fernmetastasierung (M-Status) erstmals auch den …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) has still a dismal prognosis. To
improve treatment, personalized medicine uses next-generation DNA sequencing to monitor …