Exposure of biological molecules to oxidants is inevitable and therefore commonplace.
Oxidative stress in cells arises from both external agents and endogenous processes that …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Covalent crosslinks within or between proteins play a key role in determining the structure
and function of proteins. Some of these are formed intentionally by either enzymatic or …

Essential metals including iron (Fe) and manganese (Mn) with known physiological
functions in human body play an important role in cell homeostasis. Excessive exposure to …

Parkinson's disease is the second most common neurodegenerative disorder worldwide.
Neurodegeneration in this pathology is characterized by the loss of dopaminergic neurons …

Objectives Chamomile has long been used as a medicinal plant due to its antioxidative and
anti-inflammatory activity. Apigenin-7-O-glucoside (AG) is one of the major ethanol extract …

Parkinson's disease (PD) is becoming prevalent with the increasingly ageing global
population. PD is a multi-factorial disease for which there is currently no cure but only …

The amyloid-β (Aβ) peptides are key molecules in Alzheimer's disease (AD) pathology. They
interact with cellular membranes, and can bind metal ions outside the membrane. Certain …

Introduction: Protein cross-links are common in biological systems and are generated both
deliberately as a part of normal metabolism and also accidently as a result of exposure to …

Copper ion-catalyzed oxidation of yeast SOD1 (ySOD1) was examined to determine early
oxidative modifications, including oxidation of a crucial disulfide bond, and the structural and …