The fact that transposable elements (TEs) can influence host gene expression was first
recognized more than 50 years ago. However, since that time, TEs have been widely …

The control and coordination of eukaryotic gene expression rely on transcriptional and post-
transcriptional regulatory networks. Although progress has been made in mapping the …

Genomes are vulnerable to selfish genetic elements (SGEs), which enhance their own
transmission relative to the rest of an individual's genome but are neutral or harmful to the …

More than 20 years ago, immunologists discovered that resistance and susceptibility to
experimental infection with the intracellular protozoan Leishmania major was associated …

Leishmania has a plastic genome, and drug pressure can select for gene copy number
variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to …

Kinetoplastids branched early from the eukaryotic lineage and include several parasitic
protozoan species. Up to several hundred kinetoplastid genes are co-transcribed into …

The parasites Leishmania spp., Trypanosoma brucei, and Trypanosoma cruzi are the
trypanosomatid protozoa that cause the deadly human diseases leishmaniasis, African …

Transposable elements (TEs) may contribute to evolutionary innovations through the
rewiring of networks by supplying ready-to-use cis regulatory elements. Genes on the …

Gene amplification of specific loci has been described in all kingdoms of life. In the
protozoan parasite Leishmania, the product of amplification is usually part of …

Antimonials remain the first line drug against the protozoan parasite Leishmania but their
efficacy is threatened by resistance. We carried out a RNA expression profiling analysis …