Protein complexes that contain chromatin-modifying enzymes have an important role in
regulating gene expression. Recent studies have shown that a single transcription factor, the …

The release of intercellular messengers from synaptic (SVs) and dense-core vesicles
(DCVs) constitutes the primary mechanism for communication between neighboring or …

Sensory hair cells are essential for hearing and balance. Their development from epithelial
precursors has been extensively characterized with respect to transcriptional regulation, but …

Pheochromocytomas in patients with von Hippel-Lindau (VHL) syndrome and multiple
endocrine neoplasia type 2 (MEN 2) differ in the types and amounts of catecholamines …

Astrocytes are the brain nonnerve cells that are competent for gliosecretion, ie, for
expression and regulated exocytosis of clear and dense-core vesicles (DCVs). We …

Reversible ubiquitylation of proteins contributes to their integrity, abundance and activity.
The RE1-silencing transcription factor (REST) plays key physiological roles and is …

Purpose: Specific markers of circulating tumor cells may be informative in managing lung
cancer. Because the RE-1 silencing transcription factor (REST/NRSF) is a transcriptional …

The nervous system contains a multitude of cell types which are specified during
development by cascades of transcription factors acting combinatorially. Some of these …

Processes underlying the formation of dense core secretory granules (DCGs) of
neuroendocrine cells are poorly understood. Here, we present evidence that DCG …

Neuropathic pain is characterized by complicated combination of positive (eg, hyperalgesia
and allodynia) and negative (eg, hypoesthesia and hypoalgesia) symptoms, and is often …