Membrane receptors and ion channels respond to various stimuli and relay that information
across the plasma membrane by triggering specific and timed processes. These include …

Synthetic optogenetics is an emerging optical technique that enables users to photocontrol
molecules, proteins, and cells in vitro and in vivo. This is achieved by use of synthetic …

Neurons within the tumor microenvironment promote cancer progression; thus, their local
targeting has potential clinical benefits. We designed PEGylated lipid nanoparticles loaded …

The N-methyl-D-aspartate receptors (NMDARs; GluNRS) are glutamate receptors,
commonly located at excitatory synapses. Mutations affecting receptor function often lead to …

Purposeful induction of fever for healing, including the treatment of epilepsy, was used over
2000 years ago by Hippocrates. More recently, fever has been demonstrated to rescue …

The Kv4. 2 potassium channel plays established roles in neuronal excitability, while also
being implicated in plasticity. Current means to study the roles of Kv4. 2 are limited …

Emerging genetically-encoded Ca2+-indicators (GECIs) are intensiometric reporters that
increase in fluorescence when bound to Ca2+; highly suited for studying calcium-signaling …

The widespread use of rodents in neuroscience has prompted the development of optimized
viral variants for transduction of brain cells, in vivo. However, many of the viruses developed …

N-methyl-D-aspartate receptors (NMDARs emerging from GRIN genes) are tetrameric
receptors that form diverse channel compositions in neurons, typically consisting of two …

Mutations within various N‐methyl-D-aspartate receptor (NMDAR) subunits are tightly
associated with severe pediatric neurodevelopmental disorders and encephalopathies …