[HTML][HTML] The burden and risks of emerging complications of diabetes mellitus

D Tomic, JE Shaw, DJ Magliano - Nature Reviews Endocrinology, 2022 - nature.com
The traditional complications of diabetes mellitus are well known and continue to pose a
considerable burden on millions of people living with diabetes mellitus. However, advances …

A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives

J Reed, S Bain, V Kanamarlapudi - Diabetes, Metabolic Syndrome …, 2021 - Taylor & Francis
Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …

Lifestyle factors, self-management and patient empowerment in diabetes care

E Lambrinou, TB Hansen… - European journal of …, 2019 - journals.sagepub.com
Although management of diabetes mellitus is improving, inadequately managed cases still
exist. Prevention of diabetes mellitus requires an integrated and holistic approach based on …

[HTML][HTML] Moderate Exercise Suppresses NF-κB Signaling and Activates the SIRT1-AMPK-PGC1α Axis to Attenuate Muscle Loss in Diabetic db/db Mice

HW Liu, SJ Chang - Frontiers in physiology, 2018 - frontiersin.org
The clear mechanism of moderate exercise training (Ex) in attenuating muscle loss remains
elusive in diabetes. We investigated the effects of moderate exercise training on diabetes …

[HTML][HTML] Diabetic muscular atrophy: molecular mechanisms and promising therapies

Y Shen, M Li, K Wang, G Qi, H Liu, W Wang… - Frontiers in …, 2022 - frontiersin.org
Diabetes mellitus (DM) is a typical chronic disease that can be divided into 2 types,
dependent on insulin deficiency or insulin resistance. Incidences of diabetic complications …

The association between sarcopenia and diabetes: from pathophysiology mechanism to therapeutic strategy

H Chen, X Huang, M Dong, S Wen… - … Syndrome and Obesity, 2023 - Taylor & Francis
Diabetes and sarcopenia are emerging as serious public health issues. Sarcopenia, an age-
related disorder characterized by loss of skeletal muscle mass and function, is recognized …

Mesenchymal stromal cells ameliorate diabetes‐induced muscle atrophy through exosomes by enhancing AMPK/ULK1‐mediated autophagy

J Song, J Liu, C Cui, H Hu, N Zang… - Journal of cachexia …, 2023 - Wiley Online Library
Background Diabetes and obesity are associated with muscle atrophy that reduces life
quality and lacks effective treatment. Mesenchymal stromal cell (MSC)‐based therapy can …

Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway

WY Fang, YT Tseng, TY Lee, YC Fu… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Increasing evidence suggests systemic inflammation‐caused
skeletal muscle atrophy as a major clinical feature of cachexia. Triptolide obtained from …

Pathophysiology of sarcopenia: genetic factors and their interplay with environmental factors

AM Aslam, EB Ma, JY Huh - Metabolism, 2023 - Elsevier
Sarcopenia is a geriatric disorder characterized by a progressive decline in muscle mass
and function. This disorder has been associated with a range of adverse health outcomes …

Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a

MJ Kang, JW Moon, JO Lee, JH Kim… - Journal of Cachexia …, 2022 - Wiley Online Library
Background Skeletal muscle atrophy is a severe condition that involves loss of muscle mass
and quality. Drug intake can also cause muscle atrophy. Biguanide metformin is the first‐line …