Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Targeted immunotherapy has improved patient survival in head and neck squamous cell
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …

Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

TP53 is the most frequently mutated gene in human cancer. It encodes the tumor suppressor
protein p53, which suppresses tumorigenesis by acting as a critical transcription factor that …

Simple Summary The characteristic metabolic hallmark of cancer cells is the massive
catabolism of glucose by glycolysis, even under aerobic conditions—the so-called Warburg …

Head and neck squamous cell carcinomas (HNSCC) are characterized by strong cellular
and molecular heterogeneity and treatment resistance entailing poor survival. Besides cell …

The tumor microenvironment (TME) is a significant contributor to cancer progression
containing complex connections between cellular and chemical components and provides a …

Simple Summary Cancer-associated fibroblasts are important players of the tumour
microenvironment. They influence numerous processes during tumour development and …

Objectives Exosome-mediated reciprocal crosstalk between tumor and stromal cells plays a
crucial role in tumor development and progression. This study investigated whether …