Precision medicine is about matching the right drugs to the right patients. Although this
approach is technology agnostic, in cancer there is a tendency to make precision medicine …

Phenotypically identical cells can dramatically vary with respect to behavior during their
lifespan and this variation is reflected in their molecular composition such as the …

Acute myeloid leukemia (AML) manifests as phenotypically and functionally diverse cells,
often within the same patient. Intratumor phenotypic and functional heterogeneity have been …

The genetic, functional or compositional heterogeneity of healthy and diseased tissues
presents major challenges in drug discovery and development. Such heterogeneity hinders …

New high-dimensional, single-cell technologies offer unprecedented resolution in the
analysis of heterogeneous tissues. However, because these technologies can measure …

The existence of cellular heterogeneity and its central relevance to biological phenomena
provides a strong rationale for a need for analytical methods that enable analysis at the …

Individual cell heterogeneity within a population can be critical to its peculiar function and
fate. Subpopulations studies with mixed mutants and wild types may not be as informative …

Flow cytometry is an essential tool for dissecting the functional complexity of hematopoiesis.
We used single-cell “mass cytometry” to examine healthy human bone marrow, measuring …

To enable the detection of expression signatures specific to individual cells, we developed
PLAYR (proximity ligation assay for RNA), a method for highly multiplexed transcript …

Cancer is often considered a genetic disease. However, much of the enormous plasticity of
cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and …