Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation
Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …
The effect of icariin on bone metabolism and its potential clinical application
Z Wang, D Wang, D Yang, W Zhen, J Zhang… - Osteoporosis …, 2018 - Springer
Osteoporosis is a bone disease characterized by reduced bone mass, which leads to
increased risk of bone fractures, and poses a significant risk to public health, especially in …
increased risk of bone fractures, and poses a significant risk to public health, especially in …
Osteocyte apoptosis: the roles and key molecular mechanisms in resorption-related bone diseases
J Ru, Y Wang - Cell death & disease, 2020 - nature.com
Vital osteocytes have been well known to function as an important orchestrator in the
preservation of robustness and fidelity of the bone remodeling process. Nevertheless, some …
preservation of robustness and fidelity of the bone remodeling process. Nevertheless, some …
Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii
C Li, Q Li, Q Mei, T Lu - Life Sciences, 2015 - Elsevier
Herba Epimedii is an important medicinal plant which has been used in various traditional
Chinese formulations for thousands of years as well as in modern proprietary traditional …
Chinese formulations for thousands of years as well as in modern proprietary traditional …
FN1 promotes chondrocyte differentiation and collagen production via TGF-β/PI3K/Akt pathway in mice with femoral fracture
H Zhang, X Chen, P Xue, X Ma, J Li, J Zhang - Gene, 2021 - Elsevier
Fibronectin (FN) functions as a potent stimulator of osteogenic differentiation, and bone
fracture healing. In FN family, FN1 acts as an interactive protein gene product to mediate …
fracture healing. In FN family, FN1 acts as an interactive protein gene product to mediate …
Effects of flavonoids incorporated biological macromolecules based scaffolds in bone tissue engineering
SP Soundarya, V Sanjay, AH Menon, S Dhivya… - International journal of …, 2018 - Elsevier
Skeletal tissue damage caused by trauma, injury, or disease can often result in considerable
morbidity and the need for new, more reliable strategies for skeletal regeneration. So, to …
morbidity and the need for new, more reliable strategies for skeletal regeneration. So, to …
Icariin induces osteogenic differentiation of bone mesenchymal stem cells in a MAPK‐dependent manner
Y Wu, L Xia, Y Zhou, Y Xu, X Jiang - Cell Proliferation, 2015 - Wiley Online Library
Objectives Icariin, a flavonoid isolated from Epimedium pubescens, has previously been
identified to exert beneficial effects on preventing bone loss and promoting bone …
identified to exert beneficial effects on preventing bone loss and promoting bone …
Molecular signaling mechanisms behind polyphenol-induced bone anabolism
E Torre - Phytochemistry Reviews, 2017 - Springer
For millennia, in the different cultures all over the world, plants have been extensively used
as a source of therapeutic agents with wide-ranging medicinal applications, thus becoming …
as a source of therapeutic agents with wide-ranging medicinal applications, thus becoming …
Natural products from Chinese medicines with potential benefits to bone health
Osteoporosis is a progressive, systemic bone disorder characterized by loss of bone mass
and microstructure, leading to reduced bone strength and increased risk of fracture. It is …
and microstructure, leading to reduced bone strength and increased risk of fracture. It is …
Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism
J Lin, J Zhu, Y Wang, N Zhang, HJ Gober, X Qiu… - Bioscience …, 2017 - jstage.jst.go.jp
Postmenopausal osteoporosis is a systemic metabolic skeletal disease generally ascribable
to a dearth of estrogen. Whether traditional Chinese medicine is effective in management of …
to a dearth of estrogen. Whether traditional Chinese medicine is effective in management of …