Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases arising from the bone marrow (BM), and approximately …

Our understanding of the genetics of acute myeloid leukemia (AML) development from
myelodysplastic syndrome (MDS) has advanced significantly as a result of next-generation …

More than 90% of patients with myelodysplastic/myeloproliferative neoplasms (MDSs/MPNs)
harbor somatic mutations in myeloid-related genes, but still, current diagnostic criteria do not …

Purpose We investigated the effect on outcome of measurable or minimal residual disease
(MRD) status after each induction course to evaluate the extent of its predictive value for …

Myelodysplastic syndromes (MDS) are heterogeneous neoplastic disorders of
hematopoietic stem cells (HSCs). The current standard of care for patients with MDS is …

Hematopoietic clones harboring specific mutations may expand over time. However, it
remains unclear how different cellular stressors influence this expansion. Here we …

Myelodysplastic syndrome (MDS) typically presents in older adults with the acquisition of
age-related somatic mutations, whereas MDS presenting in children and younger adults is …

Acute myeloid leukemias (AML) are characterized by mutations of tumor suppressor and
oncogenes, involving distinct genes in adults and children. While certain mutations have …

Anemia is a major and currently poorly understood clinical manifestation of hematopoietic
aging. Upon aging, hematopoietic clones harboring acquired leukemia-associated …

Human cancers arise through the sequential acquisition of somatic mutations that create
successive clonal populations. Human cancer evolution models could help illuminate this …