Glioma is the most common type of primary CNS tumor, composed of cells that resemble
normal glial cells. Recent genetic studies have provided insight into the inter-tumoral …

Medulloblastoma is a highly malignant pediatric brain tumor characterized by its aggressive
nature and limited treatment options. Metabolic changes have recently emerged as key …

Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed
functions of chromatin regulators and transcription factors. Identifying targetable epigenetic …

Suspension and imaging cytometry techniques that simultaneously measure hundreds of
cellular features are powering a new era of cell biology and transforming our understanding …

Simple Summary We review the role of chromatin and epigenetic dysregulation in therapy
resistance in glioblastoma. We discuss how epigenetic and genetic forces may cooperate to …

Quiescence is a state of cell cycle arrest, allowing cancer cells to evade anti-proliferative
cancer therapies. Quiescent cancer stem cells are thought to be responsible for treatment …

Epithelial cancers have served as a paradigm to study tumor dissemination but recent data
have highlighted significant differences with nonepithelial cancers. Here, we review the …

Schizophrenia is a significant worldwide health concern, affecting over 20 million individuals
and contributing to a potential reduction in life expectancy by up to 14.5 years. Despite its …

The central nervous system develops from a pool of neural progenitors which, depending on
their location and time of division, generate cells committed to differentiate into specific kinds …

Microglia play key roles in shaping synaptic connectivity during neural circuits development.
Whether microglia display human-specific features of structural and functional maturation is …