Targeting cellular senescence in cancer and aging: Roles of p53 and its isoforms
J Beck, C Turnquist, I Horikawa, C Harris - Carcinogenesis, 2020 - academic.oup.com
Cellular senescence and the associated secretory phenotype (SASP) promote disease in
the aged population. Targeting senescent cells by means of removal, modulation of SASP or …
the aged population. Targeting senescent cells by means of removal, modulation of SASP or …
p53 isoforms as cancer biomarkers and therapeutic targets
Simple Summary The well-known tumor suppressor protein p53 plays important roles in
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …
Evaluation and comparison of computational tools for RNA-seq isoform quantification
Background Alternatively spliced transcript isoforms are commonly observed in higher
eukaryotes. The expression levels of these isoforms are key for understanding normal …
eukaryotes. The expression levels of these isoforms are key for understanding normal …
Gene length corrected trimmed mean of M-values (GeTMM) processing of RNA-seq data performs similarly in intersample analyses while improving intrasample …
M Smid, RRJ Coebergh van den Braak… - BMC …, 2018 - Springer
Background Current normalization methods for RNA-sequencing data allow either for
intersample comparison to identify differentially expressed (DE) genes or for intrasample …
intersample comparison to identify differentially expressed (DE) genes or for intrasample …
The emerging landscape of p53 isoforms in physiology, cancer and degenerative diseases
T Anbarasan, JC Bourdon - International journal of molecular sciences, 2019 - mdpi.com
p53, first described four decades ago, is now established as a master regulator of cellular
stress response, the “guardian of the genome”. p53 contributes to biological robustness by …
stress response, the “guardian of the genome”. p53 contributes to biological robustness by …
Susceptibility to chronic inflammation: an update
Chronic inflammation is defined by the persistence of inflammatory processes beyond their
physiological function, resulting in tissue destruction. Chronic inflammation is implicated in …
physiological function, resulting in tissue destruction. Chronic inflammation is implicated in …
∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
Abstract∆ 122p53 mice (a model of∆ 133p53 isoform) are tumour-prone, have extensive
inflammation and elevated serum IL-6. To investigate the role of IL-6 we crossed∆ 122p53 …
inflammation and elevated serum IL-6. To investigate the role of IL-6 we crossed∆ 122p53 …
The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer
M Kazantseva, S Mehta, RA Eiholzer, G Gimenez… - Cell death & …, 2019 - nature.com
Prostate cancer is the second most common cancer in men, for which there are no reliable
biomarkers or targeted therapies. Here we demonstrate that elevated levels of Δ133TP53β …
biomarkers or targeted therapies. Here we demonstrate that elevated levels of Δ133TP53β …
Correlation between RNA-Seq and microarrays results using TCGA data
L Chen, F Sun, X Yang, Y Jin, M Shi, L Wang, Y Shi… - Gene, 2017 - Elsevier
RNA sequencing (RNA-Seq) and microarray are two of the most commonly used high-
throughput technologies for transcriptome profiling; however, they both have their own …
throughput technologies for transcriptome profiling; however, they both have their own …
Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
N Arsic, T Slatter, G Gadea, E Villain, A Fournet… - Nature …, 2021 - nature.com
The p53 isoform, Δ133p53β, is critical in promoting cancer. Here we report that Δ133p53β
activity is regulated through an aggregation-dependent mechanism. Δ133p53β aggregates …
activity is regulated through an aggregation-dependent mechanism. Δ133p53β aggregates …