Cellular senescence and the associated secretory phenotype (SASP) promote disease in
the aged population. Targeting senescent cells by means of removal, modulation of SASP or …

Simple Summary The well-known tumor suppressor protein p53 plays important roles in
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …

Background Alternatively spliced transcript isoforms are commonly observed in higher
eukaryotes. The expression levels of these isoforms are key for understanding normal …

Background Current normalization methods for RNA-sequencing data allow either for
intersample comparison to identify differentially expressed (DE) genes or for intrasample …

p53, first described four decades ago, is now established as a master regulator of cellular
stress response, the “guardian of the genome”. p53 contributes to biological robustness by …

Chronic inflammation is defined by the persistence of inflammatory processes beyond their
physiological function, resulting in tissue destruction. Chronic inflammation is implicated in …

Abstract∆ 122p53 mice (a model of∆ 133p53 isoform) are tumour-prone, have extensive
inflammation and elevated serum IL-6. To investigate the role of IL-6 we crossed∆ 122p53 …

Prostate cancer is the second most common cancer in men, for which there are no reliable
biomarkers or targeted therapies. Here we demonstrate that elevated levels of Δ133TP53β …

RNA sequencing (RNA-Seq) and microarray are two of the most commonly used high-
throughput technologies for transcriptome profiling; however, they both have their own …

The p53 isoform, Δ133p53β, is critical in promoting cancer. Here we report that Δ133p53β
activity is regulated through an aggregation-dependent mechanism. Δ133p53β aggregates …