Hantavirus in humans: a review of clinical aspects and management

PA Vial, M Ferrés, C Vial, J Klingström… - The Lancet Infectious …, 2023 - thelancet.com
Hantavirus infections are part of the broad group of viral haemorrhagic fevers. They are also
recognised as a distinct model of an emergent zoonotic infection with a global distribution …

A Brief History of Bunyaviral Family Hantaviridae

JH Kuhn, CS Schmaljohn - Diseases, 2023 - mdpi.com
The discovery of Hantaan virus as an etiologic agent of hemorrhagic fever with renal
syndrome in South Korea in 1978 led to identification of related pathogenic and …

Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

E Mittler, A Serris, ES Esterman, C Florez… - Science translational …, 2023 - science.org
Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved
vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody …

Recent advances in bunyavirus glycoprotein research: precursor processing, receptor binding and structure

RJG Hulswit, GC Paesen, TA Bowden, X Shi - Viruses, 2021 - mdpi.com
The Bunyavirales order accommodates related viruses (bunyaviruses) with segmented,
linear, single-stranded, negative-or ambi-sense RNA genomes. Their glycoproteins form …

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

E Mittler, AZ Wec, J Tynell, P Guardado-Calvo… - Science translational …, 2022 - science.org
The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic
fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus …

Common themes in zoonotic spillover and disease emergence: Lessons learned from bat-and rodent-borne RNA viruses

EP Williams, BM Spruill-Harrell, MK Taylor, J Lee… - Viruses, 2021 - mdpi.com
Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest
percentage of living mammals on earth. Thus, it is not surprising that these two orders …

The kidney in hantavirus infection—epidemiology, virology, pathophysiology, clinical presentation, diagnosis and management

FC Koehler, V Di Cristanziano, MR Späth… - Clinical kidney …, 2022 - academic.oup.com
Hantavirus-induced diseases are emerging zoonoses with endemic appearances and
frequent outbreaks in different parts of the world. In humans, hantaviral pathology is …

Hantavirus replication cycle—An updated structural virology perspective

K Meier, SR Thorkelsson, ERJ Quemin, M Rosenthal - Viruses, 2021 - mdpi.com
Hantaviruses infect a wide range of hosts including insectivores and rodents and can also
cause zoonotic infections in humans, which can lead to severe disease with possible fatal …

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

TB Engdahl, E Binshtein, RL Brocato, NA Kuzmina… - Elife, 2023 - elifesciences.org
Hantaviruses are high-priority emerging pathogens carried by rodents and transmitted to
humans by aerosolized excreta or, in rare cases, person-to-person contact. While infections …

Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection

TB Engdahl, NA Kuzmina, AJ Ronk, CE Mire, MA Hyde… - Cell reports, 2021 - cell.com
Summary New World hantaviruses (NWHs) are endemic in North and South America and
cause hantavirus cardiopulmonary syndrome (HCPS), with a case fatality rate of up to 40 …