Environmental pollutants and the immune response

T Suzuki, T Hidaka, Y Kumagai, M Yamamoto - Nature Immunology, 2020 - nature.com
Environmental pollution is one of the most serious challenges to health in the modern world.
Pollutants alter immune responses and can provoke immunotoxicity. In this Review, we …

Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases

M Låg, J Øvrevik, M Refsnes, JA Holme - Respiratory research, 2020 - Springer
Epidemiological studies have found strong associations between air pollution and
respiratory effects including development and/or exacerbation of asthma and chronic …

The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin

T Hidaka, E Ogawa, EH Kobayashi, T Suzuki… - Nature …, 2017 - nature.com
Atopic dermatitis is increasing worldwide in correlation with air pollution. Various organic
components of pollutants activate the transcription factor AhR (aryl hydrocarbon receptor) …

Public health and components of particulate matter: The changing assessment of black carbon

TJ Grahame, R Klemm… - Journal of the Air & Waste …, 2014 - Taylor & Francis
In 2012, the WHO classified diesel emissions as carcinogenic, and its European branch
suggested creating a public health standard for airborne black carbon (BC). In 2011, EU …

Influences of polycyclic aromatic hydrocarbon on the epigenome toxicity and its applicability in human health risk assessment

DN Das, N Ravi - Environmental research, 2022 - Elsevier
The existence of polycyclic aromatic hydrocarbons (PAHs) in ambient air is an escalating
concern worldwide because of their ability to cause cancer and induce permanent changes …

Recent Advances in Particulate Matter and Nanoparticle Toxicology: A Review of the In Vivo and In Vitro Studies

A Nemmar, JA Holme, I Rosas… - BioMed research …, 2013 - Wiley Online Library
Epidemiological and clinical studies have linked exposure to particulate matter (PM) to
adverse health effects, which may be registered as increased mortality and morbidity from …

Activation of proinflammatory responses in cells of the airway mucosa by particulate matter: oxidant-and non-oxidant-mediated triggering mechanisms

J Øvrevik, M Refsnes, M Låg, JA Holme, PE Schwarze - Biomolecules, 2015 - mdpi.com
Inflammation is considered to play a central role in a diverse range of disease outcomes
associated with exposure to various types of inhalable particulates. The initial mechanisms …

Particulate matter air pollutants and cardiovascular disease: Strategies for intervention

A Aryal, AC Harmon, TR Dugas - Pharmacology & therapeutics, 2021 - Elsevier
Air pollution is consistently linked with elevations in cardiovascular disease (CVD) and CVD-
related mortality. Particulate matter (PM) is a critical factor in air pollution-associated CVD …

Potential role of polycyclic aromatic hydrocarbons as mediators of cardiovascular effects from combustion particles

JA Holme, BC Brinchmann, M Refsnes, M Låg… - Environmental …, 2019 - Springer
Air pollution is the most important environmental risk factor for disease and premature death,
and exposure to combustion particles from vehicles is a major contributor. Human …

Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

G Crawford, MD Hayes, RC Seoane, S Ward… - Nature …, 2018 - nature.com
IgE is an ancient and conserved immunoglobulin isotype with potent immunological
function. Nevertheless, the regulation of IgE responses remains an enigma, and evidence of …