The pathogenesis of multi-organ dysfunction associated with severe acute SARS-CoV-2
infection remains poorly understood. Endothelial damage and microvascular thrombosis …

While microscopy-based cellular assays, including microfluidics, have significantly
advanced over the last several decades, there has not been concurrent development of …

The results of Voxelotor treatment in Sickle Cell Disease, as assessed through clinical
outcomes, demonstrated its efficacy in reducing hemolysis and improving hemoglobin …

The use of 'lab-on-a-chip'technology continues to rise to relevance with point of care,
personalized testing and medicine as customizable microfluidic platforms enable …

Blood viscosity is considered as a vital determinant of the efficiency of blood flow in blood-
vessel networks. The coflowing method is considered as a promising technique for …

Sickle cell disease (SCD) is an inherited monogenic disease which is characterized by
distorted red blood cells (RBCs) that cause vaso-occlusion and vasculopathy. In the …

The complex, systemic pathology of sickle cell disease is driven by multiple mechanisms
including red blood cells (RBCs) stiffened by polymerized fibers of deoxygenated sickle …

The molecular origin of sickle cell disease (SCD) has been known since 1949, but
treatments remain limited. We present the first high-throughput screening (HTS) platform for …

There is no question about the value that digital signal processing brings to the area of
biomedical research. DSP processors are used to sample and process the analog inputs …

The biomechanical properties of blood are considered promising label-free biomarkers for
early disease detection. Disposable pumps have been suggested as replacements for bulky …