Drugs that target dynamic microtubules: a new molecular perspective
RA Stanton, KM Gernert, JH Nettles… - Medicinal research …, 2011 - Wiley Online Library
Microtubules have long been considered an ideal target for anticancer drugs because of the
essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is …
essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is …
[HTML][HTML] Chemical diversity of dietary phytochemicals and their mode of chemoprevention
Despite the advancement in prognosis, diagnosis and treatment, cancer has emerged as the
second leading cause of disease associated with death in the globe. With the remarkable …
second leading cause of disease associated with death in the globe. With the remarkable …
The noscapine chronicle: a pharmaco‐historic biography of the opiate alkaloid family and its clinical applications
Given its manifold potential therapeutic applications and amenability to modification,
noscapine is a veritable “Renaissance drug” worthy of commemoration. Perhaps the only …
noscapine is a veritable “Renaissance drug” worthy of commemoration. Perhaps the only …
Phytomedicine—Modulating oxidative stress and the tumor microenvironment for cancer therapy
YT Cheng, CC Yang, LF Shyur - Pharmacological research, 2016 - Elsevier
In spite of the current advances and achievements in systems biology and translational
medicinal research, the current strategies for cancer therapy, such as radiotherapy, targeted …
medicinal research, the current strategies for cancer therapy, such as radiotherapy, targeted …
Progress toward the development of noscapine and derivatives as anticancer agents
Many nitrogen-moiety containing alkaloids derived from plant origins are bioactive and play
a significant role in human health and emerging medicine. Noscapine, a …
a significant role in human health and emerging medicine. Noscapine, a …
Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis
SR Gundala, C Yang, R Mukkavilli, R Paranjpe… - Toxicology and applied …, 2014 - Elsevier
Dietary phytochemicals are excellent ROS-modulating agents and have been shown to
effectively enhance ROS levels beyond toxic threshold in cancer cells to ensure their …
effectively enhance ROS levels beyond toxic threshold in cancer cells to ensure their …
Polyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo
Sweet potato (Ipomoea batatas) leaves or greens, extensively consumed as a vegetable in
Africa and Asia, are an excellent source of dietary polyphenols such as anthocyanins and …
Africa and Asia, are an excellent source of dietary polyphenols such as anthocyanins and …
Noscapine, a non-addictive opioid and microtubule-inhibitor in potential treatment of glioblastoma
Noscapine is a phthalide isoquinoline alkaloid that easily traverses the blood brain barrier
and has been used for years as an antitussive agent with high safety. Despite binding opioid …
and has been used for years as an antitussive agent with high safety. Despite binding opioid …
Cell cycle arrest and apoptogenic properties of opium alkaloids noscapine and papaverine on breast cancer stem cells
S Sajadian, M Vatankhah, M Majdzadeh… - Toxicology …, 2015 - Taylor & Francis
Previous report of the vast effectiveness of opium derivatives in cancer therapy is leading us
to see possible effects of these derivatives on cancer stem cells in order to find new agent for …
to see possible effects of these derivatives on cancer stem cells in order to find new agent for …
2‐(1‐Benzotriazolyl) pyridine: A Robust Bidentate Ligand for the Palladium‐Catalyzed C C (Suzuki, Heck, Fujiwara–Moritani, Sonogashira), C N and C S …
A new class of bidentate ligand, 1‐(pyridine‐2‐yl)‐1H‐benzo [d][1, 2, 3] triazole has been
designed and employed for the palladium‐catalyzed C C (Suzuki, Heck, Fujiwara …
designed and employed for the palladium‐catalyzed C C (Suzuki, Heck, Fujiwara …