Stem cells have been shown to have the potential to provide a source of cells for
applications to tissue engineering and organ repair. The mechanisms that regulate stem cell …

Understanding how cell fate decisions are regulated is a fundamental goal of developmental
and stem cell biology. Most studies on the control of cell fate decisions address the …

The ability to create a 3D tissue structure from individual cells and then to stimulate it at will
is a major goal for both the biophysics and regenerative medicine communities. Here we …

Biophysical cues influence many aspects of cell behavior. Stiffness of the extracellular matrix
is probed by cells and transduced into biochemical signals through mechanotransduction …

In order to understand the mechanisms that guide cell fate decisions during early human
development, we closely examined the differentiation process in adherent colonies of …

Studies of mechanical signalling are typically performed by comparing cells cultured on soft
and stiff hydrogel-based substrates. However, it is challenging to independently and robustly …

Purpose of review Human pluripotent stem cells (hPSCs) are anchorage-dependent cells
that can be cultured on a variety of matrices and express integrins and the machinery for …

All cells are subjected to mechanical forces throughout their lifetimes. These forces are
sensed by cell surface adhesion receptors and trigger robust actin cytoskeletal …

The field of regenerative medicine and tissue engineering is an ever evolving field that holds
promise in treating numerous musculoskeletal diseases and injuries. An important impetus …

The fate of adult stem cells can be influenced by physical cues, including nanotopography.
However, the response of human embryonic stem cells (hESCs) to dimensionally well …