Non-steroidal anti-inflammatory drugs (NSAIDs): A current insight into its molecular mechanism eliciting organ toxicities

NK Panchal, EP Sabina - Food and Chemical Toxicology, 2023 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of medications that are routinely
been used across the world. Their analgesic, anti-inflammatory, and antipyretic effects have …

Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

P Shi, S Xie, J Yang, Y Zhang, S Han, S Su… - Frontiers in …, 2022 - frontiersin.org
Bee venom (BV), a type of defensive venom, has been confirmed to have favorable
activities, such as anti-tumor, neuroprotective, anti-inflammatory, analgesic, anti-infectivity …

Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect

F Dabbagh Moghaddam, I Akbarzadeh… - Cancer …, 2021 - Springer
Background Melittin, a peptide component of honey bee venom, is an appealing candidate
for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty …

Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms

D Ezhilarasan - Drug metabolism reviews, 2023 - Taylor & Francis
Tuberculosis (TB) remains a major global health burden. Antitubercular drugs (ATDs) such
as isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), and ethambutol are used as first …

Hepatoprotective Effect of Corm of Ensete ventricosum (Welw.) Cheesman Extract against Isoniazid and Rifampicin Induced Hepatotoxicity in Swiss Albino Mice

AD Dubiwak, TW Damtew, MW Senbetu… - Journal of …, 2021 - Wiley Online Library
Drug‐induced liver injury (DILI) is one of the cumbersome health‐related problems which
render approximately 50% of liver failure and patients to receiving liver transplantation every …

Trichopus zeylanicus ameliorates ibuprofen inebriated hepatotoxicity and enteropathy: an insight into its modulatory impact on pro/anti-inflammatory cytokines and …

NK Panchal, P Swarnalatha, SE Prince - Inflammopharmacology, 2022 - Springer
Ibuprofen is a nonsteroidal anti-inflammatory drug that is commonly used for its analgesic,
antipyretic and anti-inflammatory effects worldwide. However ibuprofen comes with serious …

[HTML][HTML] Melittin induces autophagy to alleviate chronic renal failure in 5/6-nephrectomized rats and angiotensin II-induced damage in podocytes

Y Zhang, H Xu, H Qiao, Y Zhao… - Nutrition Research and …, 2024 - synapse.koreamed.org
RESULTS In the rat 5/6 Nx, melittin reduced the 24-h urinary protein excretion and the
serum creatinine and blood urea nitrogen levels. Furthermore, the renal pathology was …

Severe pathological changes in the blood and organs of SD rats stung by honeybees

X Zheng, X Wang, Q Wang, M Liu, W Peng, Y Zhao - Toxicon, 2023 - Elsevier
With the development of beekeeping, the risk of bee stings in humans is increasing. Severe
and life-threatening toxic reactions can occur after multiple bee stings, and their …

Folic acid protects against tuberculosis-drug-induced liver injury in rats and its potential mechanism by metabolomics

L Jiang, X Gai, Y Ni, T Qiang, Y Zhang, X Kang… - The Journal of …, 2023 - Elsevier
Observational study indicated that folic acid (FA) supplementation may protect against
tuberculosis-drug-induced liver injury (TBLI). The aim is to investigate the effect and …

Preclinical liver toxicity models: advantages, limitations and recommendations

D Ezhilarasan, S Karthikeyan, N Mustapha… - Toxicology, 2024 - Elsevier
Experimental animal models are crucial for elucidating the pathophysiology of liver injuries
and for assessing new hepatoprotective agents. Drugs and chemicals such as …