Importance Five to ten percent of individuals with latent tuberculosis infection (LTBI)
progress to active tuberculosis (TB) disease. Identifying and treating LTBI is a key …

Importance Latent tuberculosis infection (LTBI) can progress to active tuberculosis disease,
causing morbidity and mortality. Objective To review the evidence on benefits and harms of …

Background Pregnancy is a risk factor for progression from latent tuberculosis infection to
symptomatic tuberculosis. However, how pregnancy influences T-cell responses to …

Mono-and multifunctional specific CD4+ and CD8+ T-cell responses were evaluated to
improve the immune-based detection of active tuberculosis (TB) and latent infection (LTBI) …

Bovine tuberculosis (bTB) is a major world-wide health problem that has been difficult to
control, due to the lack of an effective vaccine and limited ability of the tuberculin skin test …

Background Intracellular cytokine flow cytometry (ICCFC) has been explored to detect
tuberculosis (TB) infections; however, there are little data regarding its use to examine the …

Although monitoring tuberculosis (TB) infection during long-term treatment with tumour
necrosis factor (TNF) antagonists is of great importance, no monitoring strategy has yet …

Control of bovine tuberculosis (bTB) continues to be a problem world-wide because of
difficulties in identifying infected animals at all stages of infection. The use of the IFN-γ …

Background Although immune activation is associated with HIV acquisition, the nature of
inflammatory profiles that increase HIV risk, which may include responses to M. tuberculosis …

To ascertain whether multiparametric flow cytometry assessment of multifunctional
Mycobacterium tuberculosis (Mtb)-specific CD4+ and CD8+ T cells can distinguish between …