Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30
years ago, it is produced as a consequence of alternative RNA processing of the calcitonin …

Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was
first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves …

Purines have key roles in neurotransmission and neuromodulation, with their effects being
mediated by the purine and pyrimidine receptor subfamilies, P1, P2X and P2Y. Recently …

There is a brief introductory summary of purinergic signaling involving ATP storage, release,
and ectoenzymatic breakdown, and the current classification of receptor subtypes for …

Seven P2X receptor subunits have been cloned which form functional homo-and
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …

There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the
brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic …

Treating pain by inhibiting ATP activation of P2X3-containing receptors heralds an exciting
new approach to pain management, and Afferent's program marks the vanguard in a new …