Abstract Development of cardiac fibrosis and arrhythmias is controlled by the activity of and
communication between cardiomyocytes and fibroblasts in the heart. Myocyte-fibroblast …

The heart provides the body with oxygen and nutrients and assists in the removal of
metabolic waste through the blood vessels of the circulatory system. It is the first organ to …

During embryogenesis, paracrine signaling between tissues in close proximity contributes to
the determination of their respective cell fate (s) and development into functional organs …

Our understanding of the spatiotemporal regulation of cardiogenesis is hindered by the
difficulties in modeling this complex organ currently by in vitro models. Here we develop a …

The current focus on cardiovascular research reflects society's concerns regarding the
alarming incidence of cardiac-related diseases and mortality in the industrialized world and …

Transplantation of stem cells into the heart can improve cardiac function after myocardial
infarction and in chronic heart failure, but the extent of benefit and of reproducibility of this …

Heart attack remains the leading cause of death in both men and women worldwide. Stem
cell-based therapies, including the use of engineered cardiac tissues, have the potential to …

The FGF family comprises 22 members with diverse functions in development and health.
FGF10 specifically activates FGFR2b in a paracrine manner with heparan sulfate as a co …

Efficient generation of cardiomyocytes from human-induced pluripotent stem cells (hiPSCs)
is important for their application in basic and translational studies. Space microgravity can …

Aims Promoting cardiomyocyte renewal represents a major therapeutic approach for heart
regeneration and repair. Our study aims to investigate the relevance of FGF10 as a potential …