Obesity is highly prevalent worldwide and is associated with significant morbidity and
mortality. The focus of this review is to delineate the changes in gastrointestinal motility …

Before the discovery of leptin, any adverse effects of obesity were attributed to mechanical
stress on cardiovascular and musculoskeletal systems, but now it is known that adipocytes …

Background & Aims Gastrointestinal (GI) motility is regulated by serotonin (5-
hydroxytryptamine [5-HT]), which is primarily produced by enterochromaffin (EC) cells in the …

Background Serotonin (5‐hydroxytryptamine, 5HT) is involved in hypothalamic regulation of
energy consumption. Also, the gut microbiome can influence neuronal signaling to the brain …

Background & Aims A high-fat diet (HFD) can cause serious health problems, including
alteration of gastrointestinal transit, the exact mechanism of which is not clear. Several …

Abstract Background Serotonin (5-hydroytryptamine or 5HT) is associated with numerous
behavioral and psychological factors and is a biochemical marker of mood. 5HT is involved …

Inflammation, decreased levels of circulating endothelial nitric oxide (eNO) and brain-
derived neurotrophic factor (BDNF), altered activity of hypothalamic neurotransmitters …

Background Constipation is one of the most common gastrointestinal complaints. Although
the causes of constipation are varied, dietary habits have a significant influence. Excessive …

Background Constipation is highly prevalent in the United States. The association of dietary
fat intake with constipation has not been well studied. We recently reported that mice fed a …

CRISPR-Cas9-mediated leptin (Lep) knockout (KO) mice exhibited prominent phenotypes
for constipation, even though they were not compared with other model animals. This study …