Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular
processes. Deregulation of FGFR signalling is observed in a subset of many cancers …

Fibroblast growth factors (FGFs) and their receptors control a wide range of biological
functions, regulating cellular proliferation, survival, migration and differentiation. Although …

Skeletal muscle aging results in a gradual loss of skeletal muscle mass, skeletal muscle
function and regenerative capacity, which can lead to sarcopenia and increased mortality …

Amplification of fibroblast growth factor receptor 1 (FGFR1) occurs in∼ 10% of breast
cancers and is associated with poor prognosis. However, it is uncertain whether …

FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays
an important role in normal organ, vascular, and skeletal development. Deregulation of …

Receptor tyrosine kinases (RTK s) are a large family of cell surface receptors that sense
growth factors and hormones and regulate a variety of cell behaviours in health and …

Adoptive immunotherapy with T cells expressing chimeric antigen receptors (CAR) has had
limited success for solid tumors in early-phase clinical studies. We reasoned that introducing …

Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic
cancer progression. MDSC regulation is widely variable even among patients harbouring …

Fibroblast growth factors and their signaling receptors have been associated with multiple
biological activities, including proliferation, differentiation and motility. Consequently, they …