FK506 binding protein 51 or FKBP5 is a co-chaperone of hsp90 which regulates
glucocorticoid receptor (GR) sensitivity. When it is bound to the receptor complex, cortisol …

The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …

A concatenation of findings from preclinical and clinical studies support a preeminent
function for the corticotropin-releasing factor (CRF) system in mediating the physiological …

The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …

This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …

Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …

Objective: The binding protein FKBP5 is an important modulator of the function of the
glucocorticoid receptor, the main receptor of the stress hormone system. This turns the …

The search for novel drugs for treating psychiatric disorders is driven by the growing medical
need to improve on the effectiveness and side-effect profile of currently available therapies …

A number of candidate gene studies focused on major depression (MD) and antidepressant
(AD) efficacy have been carried out, but results mainly remain inconclusive. We performed a …

Childhood maltreatment and depressive disorders have both been associated with a
dysregulation of the hypothalamic–pituitary–adrenal axis. The FKBP5 gene codes for a co …