The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders
EB Binder - Psychoneuroendocrinology, 2009 - Elsevier
FK506 binding protein 51 or FKBP5 is a co-chaperone of hsp90 which regulates
glucocorticoid receptor (GR) sensitivity. When it is bound to the receptor complex, cortisol …
glucocorticoid receptor (GR) sensitivity. When it is bound to the receptor complex, cortisol …
Key role of CRF in the skin stress response system
AT Slominski, MA Zmijewski, B Zbytek… - Endocrine …, 2013 - academic.oup.com
The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …
The CRF system, stress, depression and anxiety—insights from human genetic studies
EB Binder, CB Nemeroff - Molecular psychiatry, 2010 - nature.com
A concatenation of findings from preclinical and clinical studies support a preeminent
function for the corticotropin-releasing factor (CRF) system in mediating the physiological …
function for the corticotropin-releasing factor (CRF) system in mediating the physiological …
[HTML][HTML] Personalized medicine in psychiatry: problems and promises
U Ozomaro, C Wahlestedt, CB Nemeroff - BMC medicine, 2013 - Springer
The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …
physiologic characteristics play a significant role in both disease vulnerability and in …
Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder
M Kato, A Serretti - Molecular psychiatry, 2010 - nature.com
This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …
[HTML][HTML] The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
Interaction of FKBP5 Gene Variants and Adverse Life Events in Predicting Depression Onset: Results From a 10-Year Prospective Community Study
P Zimmermann, T Brückl, A Nocon… - American Journal of …, 2011 - Am Psychiatric Assoc
Objective: The binding protein FKBP5 is an important modulator of the function of the
glucocorticoid receptor, the main receptor of the stress hormone system. This turns the …
glucocorticoid receptor, the main receptor of the stress hormone system. This turns the …
Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?
G Griebel, F Holsboer - Nature reviews Drug discovery, 2012 - nature.com
The search for novel drugs for treating psychiatric disorders is driven by the growing medical
need to improve on the effectiveness and side-effect profile of currently available therapies …
need to improve on the effectiveness and side-effect profile of currently available therapies …
Pharmacogenetics in major depression: a comprehensive meta-analysis
A number of candidate gene studies focused on major depression (MD) and antidepressant
(AD) efficacy have been carried out, but results mainly remain inconclusive. We performed a …
(AD) efficacy have been carried out, but results mainly remain inconclusive. We performed a …
[HTML][HTML] Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population
K Appel, C Schwahn, J Mahler, A Schulz… - …, 2011 - nature.com
Childhood maltreatment and depressive disorders have both been associated with a
dysregulation of the hypothalamic–pituitary–adrenal axis. The FKBP5 gene codes for a co …
dysregulation of the hypothalamic–pituitary–adrenal axis. The FKBP5 gene codes for a co …