Pyridine (py) is an important heterocyclic compound and is an integral part of various natural
products. There are various medicines containing py ring system being available in the …

Thiosemicarbazones (TSCs) are a class of Schiff bases usually obtained by the
condensation of thiosemicarbazide with a suitable aldehyde or ketone. TSCs have been the …

Abstract New azafluorenones, 2-aryl-4-(4-hydroxyphenyl)-5H-indeno [1, 2-b] pyridin-5-ones,
were prepared to evaluate their cytotoxic/anticancer properties, also their inhibitory effects …

Inhibition of Heat-shock protein 90 (Hsp90) is considered an attractive route in fighting
against cancer proliferation. Herein, new indene derivatives targeting Hsp90 were …

Chalcones and Mannich bases are a group of compounds known for their cytotoxicities. In
this study restricted chalcone analogue, compound 2-(4-hydroxybenzylidene)-2, 3 …

DNA is considered one of the most promising targets of molecules with anticancer activity
potential. Its key role in various cell division mechanisms, which commands the intense …

To develop effective therapeutics for inflammatory bowel disease (IBD), 2-benzylidene-2, 3-
dihydro-1 H-inden-1-one and benzofuran-3 (2H)-one derivatives, were designed and …

Colorectal cancer (CRC) is the third most common cancer globally, with high mortality.
Metastatic CRC is incurable in most cases, and multiple drug therapy can increase patients' …

Abstract (5Z, 9Z)-11-Phenylundeca-5, 9-dienoic acid was stereoselectively synthesized,
based on original cross-cyclomagnesiation of 2-(hepta-5, 6-dien-1-yloxy) tetrahydro-2H …

A new series of thirty-six dihydroxylated 2, 6-diphenyl-4-aryl pyridines containing hydroxyl
groups at the ortho, meta, or para position of 2-and 6-phenyl rings attached to the central …