REVIEW Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized
machinery. The central component of this machinery is a proteolytic system involving a …

Apoptosis, or programmed cell death, is an essential physiological process that plays a
critical role in development and tissue homeostasis. The progress of apoptosis is regulated …

Survivin, as a member of the inhibitor of apoptosis proteins (IAPs) family, acts as a
suppressor of apoptosis and plays a central role in cell division. Survivin has been …

The'inhibitor of apoptosis'(IAP) gene family, which was discovered less than a decade ago,
encodes a group of structurally related proteins that, in addition to their ability to suppress …

Survivin is a member of the inhibitor of apoptosis protein (IAP) family. We investigated the
antiapoptotic mechanism of Survivin, as well as its expression in 60 human tumor cell lines …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential
loss of the dopaminergic neurons of the substantia nigrapars compacta. Although the …

The death morphology commonly known as apoptosis results from a post-translational
pathway driven largely by specific limited proteolysis. In the last decade the structural basis …

Survivin, an apoptosis inhibitor/cell-cycle regulator, is critically required for suppression of
apoptosis and ensuring normal cell division in the G2/M phase of the cell cycle. It is highly …

The molecular mechanism (s) that regulate apoptosis by caspase inhibition remain poorly
understood. The main endogenous inhibitors are members of the IAP family and are …

The inhibitor of apoptosis protein family has been characterized over the past 5 years,
initially in baculovirus and more recently in metazoans. The IAPs are a widely expressed …