RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

The transcription elongation factor Spt5 is conserved from bacteria to humans. In
eukaryotes, Spt5 forms a complex with Spt4 and regulates processive transcription …

Based on in vitro studies, it has been demonstrated that the DSIF complex, composed of
SPT4 and SPT5, regulates the elongation stage of transcription catalyzed by RNA …

Various transcript elongation factors (TEFs) including modulators of RNA polymerase II
(RNAPII) activity and histone chaperones tune the efficiency of transcription in the chromatin …

Spt5 is an essential and conserved factor that functions in transcription and co-
transcriptional processes. However, many aspects of the requirement for Spt5 in …

Spt5 is a highly conserved RNA polymerase II (Pol II)‐associated pausing and elongation
factor. However, its impact on global elongation and Pol II processivity in mammalian cells …

The human genome encodes large numbers of non-coding RNAs, including divergent
antisense transcripts at transcription start sites (TSSs). However, molecular mechanisms by …

In C. elegans, the conserved transcription factor DAF-16/FOXO is a powerful aging regulator,
relaying dire conditions into expression of stress resistance and longevity promoting genes …

The archaeal transcription apparatus is closely related to the eukaryotic RNA polymerase
(RNAP) II system, while archaeal genomes are more similar to bacteria with densely packed …

Huntington's disease (HD) is an incurable inherited disorder caused by a repeated
expansion of glutamines in the huntingtin gene (Htt). The mutant protein causes neuronal …