Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

Guanine-rich DNA sequences can form G-quadruplexes stabilized by stacked G–G–G–G
tetrads in monovalent cation-containing solution. The length and number of individual G …

Summary G-quadruplex (G4)-forming genomic sequences, including telomeres, represent
natural replication fork barriers. Stalled replication forks can be stabilized and restarted by …

The 3′‐ends of human chromosomal DNA terminate in short single‐stranded guanine‐rich
tandem‐repeat sequences. In cancer cells, these are associated with the telomere …

Over the past decade, nucleic acid chemists have seen the spectacular emergence of
molecules designed to interact efficiently and selectively with a peculiar DNA structure …

The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter strongly controls
the transcriptional activity of the c-MYC oncogene. The purine-rich strand of the NHE III1 …

Nucleic acid sequences containing several short runs of guanine nucleotides can form
complex higher order structures, termed quadruplexes. Their occurrence has been most …

G‐quadruplexes are special secondary structures adopted in some guanine‐rich DNA
sequences. As guanine‐rich sequences are present in important regions of the eukaryotic …

G-rich DNA and RNA sequences can form four-stranded structures called G-quadruplexes.
Such structures have gained significant interest in the past decade with increasing evidence …

Telomeres are present at the ends of all eukaryotic chromosomes. Human telomeres play an
important role in critical processes underlying genome stability, cancer, and aging, and their …