Sarcopenia is a major component of the frailty syndrome, both being considered as strong
predictors of morbidity, disability, and death in older people. In this review, we explore the …

As we age, there is an age-related loss in skeletal muscle mass and strength, known as
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …

Microplastics (MPs), plastic debris smaller than 5 mm, are widely found in both marine and
freshwater ecosystems. However, few studies regarding their hazardous effects on inland …

The free radical theory of aging is almost 60 years old. As mitochondria are the principle
source of intracellular reactive oxygen species (ROS), this hypothesis suggested a central …

Nicotinamide adenine dinucleotide (NAD+) is an essential electron transporter in
mitochondrial respiration and oxidative phosphorylation. In genomic DNA, NAD+ also …

Abstract The Editors of the Journal of Alzheimer's Disease invited Professor Patrizia Mecocci
to contribute a review article focused on the importance and implications of her research on …

These practice parameters are an update of the previously-published recommendations
regarding the indications for polysomnography and related procedures in the diagnosis of …

Free radicals and other so-called 'reactive species' are constantly produced in the brain in
vivo. Some arise by 'accidents of chemistry', an example of which may be the leakage of …

Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great
volume of knowledge in the field has been accumulated. Here we attempted to organize the …

The oxidative modification of proteins by reactive species, especially reactive oxygen
species, is implicated in the etiology or progression of a panoply of disorders and diseases …