Serotonin, food intake, and obesity

KA van Galen, KW Ter Horst, MJ Serlie - Obesity Reviews, 2021 - Wiley Online Library
The role of serotonin in food intake has been studied for decades. Food intake is mainly
regulated by two brain circuitries:(i) the homeostatic circuitry, which matches energy intake …

Control of sleep and wakefulness

RE Brown, R Basheer, JT McKenna… - Physiological …, 2012 - journals.physiology.org
This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework

GF Koob, IM Colrain - Neuropsychopharmacology, 2020 - nature.com
The development of alcohol use disorder (AUD) involves binge or heavy drinking to high
levels of intoxication that leads to compulsive intake, the loss of control in limiting intake, and …

Sleep state switching

CB Saper, PM Fuller, NP Pedersen, J Lu, TE Scammell - Neuron, 2010 - cell.com
We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but
these changes in behavioral state require specific switching mechanisms in the brain that …

[HTML][HTML] Regulation of breathing and autonomic outflows by chemoreceptors

PG Guyenet - Comprehensive Physiology, 2014 - ncbi.nlm.nih.gov
Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …

The sleep switch: hypothalamic control of sleep and wakefulness

CB Saper, TC Chou, TE Scammell - Trends in neurosciences, 2001 - cell.com
More than 70 years ago, von Economo predicted a wake-promoting area in the posterior
hypothalamus and a sleep-promoting region in the preoptic area. Recent studies have …

The orexin/receptor system: molecular mechanism and therapeutic potential for neurological diseases

C Wang, Q Wang, B Ji, Y Pan, C Xu… - Frontiers in molecular …, 2018 - frontiersin.org
Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing
neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by …

[HTML][HTML] Targeting the orexin/hypocretin system for the treatment of neuropsychiatric and neurodegenerative diseases: From animal to clinical studies

M Ten-Blanco, Á Flores, L Cristino… - Frontiers in …, 2023 - Elsevier
Orexins (also known as hypocretins) are neuropeptides located exclusively in hypothalamic
neurons that have extensive projections throughout the central nervous system and bind two …

[HTML][HTML] Behavioral correlates of activity in identified hypocretin/orexin neurons

BY Mileykovskiy, LI Kiyashchenko, JM Siegel - Neuron, 2005 - cell.com
Micropipette recording with juxtacellular Neurobiotin ejection, linked micropipette-microwire
recording, and antidromic and orthodromic activation from the ventral tegmental area and …

The neurobiology of sleep and wakefulness

MD Schwartz, TS Kilduff - Psychiatric Clinics, 2015 - psych.theclinics.com
Our understanding of the neural control of sleep in large part parallels the history of
neuroscience. As new tools and methodologies have become available to the research …