Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo

D Reglodi, P Kiss, A Lubics… - Current pharmaceutical …, 2011 - ingentaconnect.com
Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and
multifunctional peptide exerting its effects via 3 main receptors (PAC1, VPAC1 and VPAC2) …

Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide

A Somogyvari-Vigh, D Reglodi - Current pharmaceutical design, 2004 - ingentaconnect.com
Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from
hypothalamic extracts on the basis of its ability to stimulate cAMP formation in pituitary cells …

PACAP is an endogenous protective factor—insights from PACAP-deficient mice

D Reglodi, P Kiss, K Szabadfi, T Atlasz… - Journal of Molecular …, 2012 - Springer
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a widespread neuropeptide
with a diverse array of biological functions. Not surprisingly, the lack of endogenous PACAP …

Role of PACAP in ischemic neural death

H Ohtaki, T Nakamachi, K Dohi, S Shioda - Journal of Molecular …, 2008 - Springer
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that was first
isolated from an ovine hypothalamus in 1989. Since its discovery, more than 2,000 papers …

Protective effects of PACAP in ischemia

D Reglodi, A Vaczy, E Rubio-Beltran… - The Journal of …, 2018 - Springer
Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide
involved, among others, in neurodevelopment, neuromodulation, neuroprotection …

PACAP as a neuroprotective factor in ischemic neuronal injuries

S Shioda, T Nakamachi - Peptides, 2015 - Elsevier
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27-or 38-amino acid
neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin …

Pituitary adenylate cyclase-activating polypeptide: focus on structure-activity relationships of a neuroprotective peptide

S Bourgault, D Vaudry, A Dejda… - Current medicinal …, 2009 - ingentaconnect.com
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid peptide that
was initially isolated from hypothalamus extracts on the basis of its ability to stimulate the …

Effect of PACAP in central and peripheral nerve injuries

A Tamas, D Reglodi, O Farkas, E Kovesdi, J Pal… - International journal of …, 2012 - mdpi.com
Pituitary adenylate cyclase activating polypeptide (PACAP) is a bioactive peptide with
diverse effects in the nervous system. In addition to its more classic role as a …

Class II G protein-coupled receptors and their ligands in neuronal function and protection

B Martin, RL De Maturana, R Brenneman… - Neuromolecular …, 2005 - Springer
G protein-coupled receptors (GPCRs) play pivotal roles in regulating the function and
plasticity of neuronal circuits in the nervous system. Among the myriad of GPCRs expressed …

PACAP and a novel stable analog protect rat brain from ischemia: Insight into the mechanisms of action

A Dejda, T Seaborn, S Bourgault, O Touzani… - Peptides, 2011 - Elsevier
Pituitary adenylate cyclase-activating polypeptide (PACAP) shows potent protective effects
in numerous models of neurological insults. However, the use of PACAP as a clinically …