A combined proteomics and metabolomics approach to assess the effects of gold nanoparticles in vitro
Omics technologies, such as proteomics or metabolomics, have to date been applied in the
field of nanomaterial safety assessment to a limited extent. To address this dearth, we …
field of nanomaterial safety assessment to a limited extent. To address this dearth, we …
State of the art of chromosome 18-Centric HPP in 2016: transcriptome and proteome profiling of liver tissue and HepG2 cells
EV Poverennaya, AT Kopylov… - Journal of Proteome …, 2016 - ACS Publications
A gene-centric approach was applied for a large-scale study of expression products of a
single chromosome. Transcriptome profiling of liver tissue and HepG2 cell line was …
single chromosome. Transcriptome profiling of liver tissue and HepG2 cell line was …
Interruption of p53-MDM2 interaction by Nutlin-3a in human lymphoma cell models initiates a cell-dependent global effect on transcriptome and proteome level
Simple Summary The activation of wild-type p53 protein in human lymphoma is a promising
therapeutic strategy. A precise interruption of a protein–protein interaction, such as the p53 …
therapeutic strategy. A precise interruption of a protein–protein interaction, such as the p53 …
Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells
J Staniek, T Kalina, G Andrieux, M Boerries… - Science …, 2024 - science.org
Defective FAS (CD95/Apo-1/TNFRSF6) signaling causes autoimmune lymphoproliferative
syndrome (ALPS). Hypergammaglobulinemia is a common feature in ALPS with FAS …
syndrome (ALPS). Hypergammaglobulinemia is a common feature in ALPS with FAS …
Deepening into intracellular signaling landscape through integrative spatial proteomics and transcriptomics in a lymphoma model
Human Proteome Project (HPP) presents a systematic characterization of the protein
landscape under different conditions using several complementary-omic techniques (LC …
landscape under different conditions using several complementary-omic techniques (LC …
Integration and comparison of transcriptomic and proteomic data for meningioma
J Dunn, VP Lenis, DA Hilton, R Warta, C Herold-Mende… - Cancers, 2020 - mdpi.com
Simple Summary Meningioma are the most common primary intracranial tumour, yet gaps in
their molecular characterisation persist and effective treatments for aggressive, recurring …
their molecular characterisation persist and effective treatments for aggressive, recurring …
Translational bioinformatics in healthcare: past, present, and future
Abstract Back in 2003, chemists, biologists, statisticians, and computational scientists came
together on one platform and brought out the entire human genome, known as The Human …
together on one platform and brought out the entire human genome, known as The Human …
Functional proteomic insights in B-cell chronic lymphocytic leukemia
Introduction: B cell chronic lymphocytic leukemia (B-CLL) is a hematological malignancy
considered as the most common leukemia in the Western world. The understanding of B cell …
considered as the most common leukemia in the Western world. The understanding of B cell …
[HTML][HTML] Recurrent NOMO1 gene deletion is a potential clinical marker in early-onset colorectal cancer and is involved in the regulation of cell migration
The incidence of early-onset colorectal cancer (EOCRC; age younger than 50 years) has
been progressively increasing over the last decades globally, with causes unexplained. A …
been progressively increasing over the last decades globally, with causes unexplained. A …
Dynamic intracellular metabolic cell signaling profiles during Ag-dependent b-cell differentiation
Human B-cell differentiation has been extensively investigated on genomic and
transcriptomic grounds; however, no studies have accomplished so far detailed analysis of …
transcriptomic grounds; however, no studies have accomplished so far detailed analysis of …