Control of the eIF4E activity: structural insights and pharmacological implications
The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA
translation has been clearly assessed in the last decades. eIF4E function is essential for …
translation has been clearly assessed in the last decades. eIF4E function is essential for …
A quick guide to small-molecule inhibitors of eukaryotic protein synthesis
SE Dmitriev, DO Vladimirov, KA Lashkevich - Biochemistry (Moscow), 2020 - Springer
Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …
A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis
X Chen, J Huang, C Yu, J Liu, W Gao, J Li… - Nature …, 2022 - nature.com
Ferroptosis is a type of lipid peroxidation-dependent cell death that is emerging as a
therapeutic target for cancer. However, the mechanisms of ferroptosis during the generation …
therapeutic target for cancer. However, the mechanisms of ferroptosis during the generation …
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …
proteins. For the majority of human proteins that contain intrinsically disordered regions …
Micropeptide CIP 2A‐BP encoded by LINC 00665 inhibits triple‐negative breast cancer progression
B Guo, S Wu, X Zhu, L Zhang, J Deng, F Li… - The EMBO …, 2020 - embopress.org
TGF‐β signaling pathway plays a key role in breast cancer metastasis. Recent studies
suggest that TGF‐β regulates tumor progression and invasion not only via transcriptional …
suggest that TGF‐β regulates tumor progression and invasion not only via transcriptional …
High throughput discovery of functional protein modifications by Hotspot Thermal Profiling
Mass spectrometry enables global analysis of posttranslationally modified proteoforms from
biological samples, yet we still lack methods to systematically predict, or even prioritize …
biological samples, yet we still lack methods to systematically predict, or even prioritize …
mTOR-dependent translation amplifies microglia priming in aging mice
L Keane, I Antignano, SP Riechers… - The Journal of …, 2021 - Am Soc Clin Investig
Microglia maintain homeostasis in the brain. However, with age, they become primed and
respond more strongly to inflammatory stimuli. We show here that microglia from aged mice …
respond more strongly to inflammatory stimuli. We show here that microglia from aged mice …
Structure-based design of pyridone–aminal eFT508 targeting dysregulated translation by selective mitogen-activated protein kinase interacting kinases 1 and 2 …
SH Reich, PA Sprengeler, GG Chiang… - Journal of medicinal …, 2018 - ACS Publications
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated
protein kinase interacting kinases (MNK) 1/2 are key regulators of mRNA translation …
protein kinase interacting kinases (MNK) 1/2 are key regulators of mRNA translation …
eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs
L Lorenzo-Orts, M Strobl, B Steinmetz, F Leesch… - EMBO …, 2024 - embopress.org
Maternal mRNAs are essential for protein synthesis during oogenesis and early
embryogenesis. To adapt translation to specific needs during development, maternal …
embryogenesis. To adapt translation to specific needs during development, maternal …
The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1
The activation of cap-dependent translation in eukaryotes requires multisite, hierarchical
phosphorylation of 4E-BP by the 1 MDa kinase mammalian target of rapamycin complex 1 …
phosphorylation of 4E-BP by the 1 MDa kinase mammalian target of rapamycin complex 1 …