Control of the eIF4E activity: structural insights and pharmacological implications

A Romagnoli, M D'Agostino, C Ardiccioni… - Cellular and Molecular …, 2021 - Springer
The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA
translation has been clearly assessed in the last decades. eIF4E function is essential for …

A quick guide to small-molecule inhibitors of eukaryotic protein synthesis

SE Dmitriev, DO Vladimirov, KA Lashkevich - Biochemistry (Moscow), 2020 - Springer
Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …

A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis

X Chen, J Huang, C Yu, J Liu, W Gao, J Li… - Nature …, 2022 - nature.com
Ferroptosis is a type of lipid peroxidation-dependent cell death that is emerging as a
therapeutic target for cancer. However, the mechanisms of ferroptosis during the generation …

Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2

TR Alderson, I Pritišanac, Đ Kolarić… - Proceedings of the …, 2023 - National Acad Sciences
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …

Micropeptide CIP 2A‐BP encoded by LINC 00665 inhibits triple‐negative breast cancer progression

B Guo, S Wu, X Zhu, L Zhang, J Deng, F Li… - The EMBO …, 2020 - embopress.org
TGF‐β signaling pathway plays a key role in breast cancer metastasis. Recent studies
suggest that TGF‐β regulates tumor progression and invasion not only via transcriptional …

High throughput discovery of functional protein modifications by Hotspot Thermal Profiling

JX Huang, G Lee, KE Cavanaugh, JW Chang… - Nature …, 2019 - nature.com
Mass spectrometry enables global analysis of posttranslationally modified proteoforms from
biological samples, yet we still lack methods to systematically predict, or even prioritize …

mTOR-dependent translation amplifies microglia priming in aging mice

L Keane, I Antignano, SP Riechers… - The Journal of …, 2021 - Am Soc Clin Investig
Microglia maintain homeostasis in the brain. However, with age, they become primed and
respond more strongly to inflammatory stimuli. We show here that microglia from aged mice …

Structure-based design of pyridone–aminal eFT508 targeting dysregulated translation by selective mitogen-activated protein kinase interacting kinases 1 and 2 …

SH Reich, PA Sprengeler, GG Chiang… - Journal of medicinal …, 2018 - ACS Publications
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated
protein kinase interacting kinases (MNK) 1/2 are key regulators of mRNA translation …

eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs

L Lorenzo-Orts, M Strobl, B Steinmetz, F Leesch… - EMBO …, 2024 - embopress.org
Maternal mRNAs are essential for protein synthesis during oogenesis and early
embryogenesis. To adapt translation to specific needs during development, maternal …

The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1

R Böhm, S Imseng, RP Jakob, MN Hall, T Maier… - Molecular cell, 2021 - cell.com
The activation of cap-dependent translation in eukaryotes requires multisite, hierarchical
phosphorylation of 4E-BP by the 1 MDa kinase mammalian target of rapamycin complex 1 …