Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due
to its sensitive location, surgical resection has high risk and therefore, chemotherapy and …

Metabolism must be tightly regulated to fulfil the dynamic requirements of cancer cells during
proliferation, migration, stemness and differentiation. Src is a node of several signals …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Although nanomedicine have greatly developed and human life span has been extended,
we have witnessed the soared incidence of central nervous system (CNS) diseases …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate
direct intercellular communication, a critical feature for the development, function, and …

Astrocytes have long been considered the supportive cells of the central nervous system, but
during the last decades, they have gained much more attention because of their active …

Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an
overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with …