Modeling neurodegeneration in Caenorhabditis elegans
KA Caldwell, CW Willicott… - Disease Models & …, 2020 - journals.biologists.com
The global burden of neurodegenerative diseases underscores the urgent need for
innovative strategies to define new drug targets and disease-modifying factors. The …
innovative strategies to define new drug targets and disease-modifying factors. The …
All the tau we cannot see
B Hyman - Annual Review of Medicine, 2023 - annualreviews.org
Alzheimer's disease (AD) was described in 1906 as a dementing disease marked by the
presence of two types of fibrillar aggregates in the brain: neurofibrillary tangles and senile …
presence of two types of fibrillar aggregates in the brain: neurofibrillary tangles and senile …
Tau protein liquid–liquid phase separation can initiate tau aggregation
S Wegmann, B Eftekharzadeh, K Tepper… - The EMBO …, 2018 - embopress.org
The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …
Tau structures
J Avila, JS Jiménez, CL Sayas, M Bolós… - Frontiers in aging …, 2016 - frontiersin.org
Tau is a microtubule-associated protein that plays an important role in axonal stabilization,
neuronal development, and neuronal polarity. In this review, we focus on the primary …
neuronal development, and neuronal polarity. In this review, we focus on the primary …
Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer's disease–conformist, nonconformist, and realistic prospects for AD pathogenesis
Background Alzheimer's disease (AD) is a fatal disease that threatens the quality of life of an
aging population at a global scale. Various hypotheses on the etiology of AD have been …
aging population at a global scale. Various hypotheses on the etiology of AD have been …
A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies
Primary tauopathies are characterized neuropathologically by inclusions containing
abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse …
abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse …
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons
The ubiquitin-proteasome system (UPS) is responsible for most selective protein
degradation in eukaryotes and regulates numerous cellular processes, including cell cycle …
degradation in eukaryotes and regulates numerous cellular processes, including cell cycle …
Modeling Alzheimer's Disease in Caenorhabditis elegans
J Alvarez, P Alvarez-Illera, J Santo-Domingo… - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of dementia. After decades of research,
we know the importance of the accumulation of protein aggregates such as β-amyloid …
we know the importance of the accumulation of protein aggregates such as β-amyloid …
Human iPSC-derived neuronal model of tau-A152T frontotemporal dementia reveals tau-mediated mechanisms of neuronal vulnerability
Frontotemporal dementia (FTD) and other tauopathies characterized by focal brain
neurodegeneration and pathological accumulation of proteins are commonly associated …
neurodegeneration and pathological accumulation of proteins are commonly associated …
Tau and axonal transport misregulation in tauopathies
Tau is a microtubule-associated protein that is involved in both normal and pathological
processes in neurons. Since the discovery and characterization of tau over 40 years ago …
processes in neurons. Since the discovery and characterization of tau over 40 years ago …