Intrinsically disordered proteins (IDPs) are enriched in signaling and regulatory functions
because disordered segments permit interaction with several proteins and hence the re-use …

Abstract The Polycomb group (PcG) proteins are transcriptional repressors that regulate
lineage choices during development and differentiation. Recent studies have advanced our …

Abstract Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector
function, high co-expression of inhibitory receptors and extensive transcriptional changes …

During cellular reprogramming, only a small fraction of cells become induced pluripotent
stem cells (iPSCs). Previous analyses of gene expression during reprogramming were …

Naive and primed pluripotency is characterized by distinct signaling requirements,
transcriptomes, and developmental properties, but both cellular states share key …

Epigenetic and epitranscriptomic networks have important functions in maintaining the
pluripotency of embryonic stem cells (ESCs) and somatic cell reprogramming. However, the …

Transcription factors (TFs) and their specific interactions with targets are crucial for
specifying gene-expression programs. To gain insights into the transcriptional regulatory …

Abstract Epithelial–mesenchymal transition (EMT), a critical process of cancer invasion and
metastasis, is associated with stemness property of cancer cells. Though Oct4 and Nanog …

Clinical application of embryonic stem (ES) cells faces difficulties regarding use of embryos,
as well as tissue rejection after implantation. One way to circumvent these issues is to …

Cancer stem cells are rare tumor cells characterized by their ability to self-renew and to
induce tumorigenesis. They are present in gliomas and may be responsible for the lethality …