Cancer management during COVID-19 pandemic: is immune checkpoint inhibitors-based immunotherapy harmful or beneficial?

S Vivarelli, L Falzone, CM Grillo, G Scandurra, F Torino… - Cancers, 2020 - mdpi.com
The coronavirus disease 2019 (COVID-19) is currently representing a global health threat
especially for fragile individuals, such as cancer patients. It was demonstrated that cancer …

Immune-checkpoint inhibitors from cancer to COVID-19: A promising avenue for the treatment of patients with COVID-19

S Vivarelli, L Falzone, F Torino… - International …, 2020 - spandidos-publications.com
The severe acute respiratory syndrome associated coronavirus-2 (SARS-CoV-2) poses a
threat to human life worldwide. Since early March, 2020, coronavirus disease 2019 (COVID …

Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis

ZB Jiang, JM Huang, YJ Xie, YZ Zhang… - Journal of Experimental …, 2020 - Springer
Background Accumulating evidence showed that regulating tumor microenvironment plays a
vital role in improving antitumor efficiency. Programmed Death Ligand 1 (PD-L1) is …

Translational considerations in nanomedicine: the oncology perspective

AA Gabizon, RTM de Rosales, NM La-Beck - Advanced Drug Delivery …, 2020 - Elsevier
Nanoparticles can provide effective control of the release rate and tissue distribution of their
drug payload, leading to major pharmacokinetic and pharmacodynamic changes vis-à-vis …

Efficacy of PD-1/L1 inhibitors in brain metastases of non-small-cell lung cancer: Pooled analysis from seven randomized controlled trials

W Li, J Jiang, L Huang, F Long - Future Oncology, 2022 - Taylor & Francis
Background: The efficacy of PD-1 or PD-L1 inhibitors in patients with brain metastases of
non-small-cell lung cancer (BM-NSCLC) is inconclusive. Materials & methods: An electronic …

Surface engineering of oncolytic adenovirus for a combination of immune checkpoint blockade and virotherapy

P Lv, X Chen, S Fu, E Ren, C Liu, X Liu, L Jiang… - Biomaterials …, 2021 - pubs.rsc.org
Advances in the development of modern cancer immunotherapy and immune checkpoint
inhibitors have dramatically changed the landscape of cancer treatment. However, most …

Challenges of cancer immunotherapy and chemotherapy during the COVID-19 pandemic

M Fathi, K Vakili, K Jazi, MA Sadeghi… - Tumori …, 2022 - journals.sagepub.com
People at high risk of morbidity and mortality from coronavirus disease 2019 (COVID-19),
including patients dealing with malignancies and patients on immunosuppressive …

Harnessing Nanomedicine to Potentiate the Chemo-Immunotherapeutic Effects of Doxorubicin and Alendronate Co-Encapsulated in Pegylated Liposomes

A Gabizon, H Shmeeda, B Draper, A Parente-Pereira… - Pharmaceutics, 2023 - mdpi.com
Encapsulation of Doxorubicin (Dox), a potent cytotoxic agent and immunogenic cell death
inducer, in pegylated (Stealth) liposomes, is well known to have major pharmacologic …

Engineered DBCO+ PD-1 Nanovesicles Carrying 1-MT for Cancer-Targeted Immunotherapy

X Xu, L Liu, H Wang, W Li, Y Zou, Y Zeng… - ACS Biomaterials …, 2022 - ACS Publications
Liver cancer cells evade immune surveillance and anticancer response through various
pathways, including the programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1) …

Strategies, Challenges, and Prospects of Nanoparticles in Gynecological Malignancies

Y Zhang, J Tian - ACS omega, 2024 - ACS Publications
Gynecologic cancers are a significant health issue for women globally. Early detection and
successful treatment of these tumors are crucial for the survival of female patients …