The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

Abstract Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a
complex array of critical cellular processes. It was initially identified in rat skeletal muscle as …

Type 2 diabetes (T2DM) commonly arises from islet β cell failure and insulin resistance.
Here, we examined the sensitivity of key islet-enriched transcription factors to oxidative …

Canonical Wnt signaling requires inhibition of Glycogen Synthase Kinase 3 (GSK3) activity,
but the molecular mechanism by which this is achieved remains unclear. Here, we report …

Both common forms of diabetes have an inflammatory pathogenesis in which immune and
metabolic factors converge on interleukin-1β as a key mediator of insulin resistance and β …

Analyses in mouse models have revealed crucial roles for MafA (musculoaponeurotic
fibrosarcoma oncogene family A) and MafB in islet β cells, with MafB being required during …

Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their
established role in human cancer—overexpression of the large Maf genes promotes the …

Production and secretion of insulin from the β-cells of the pancreas is very crucial in
maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and …

Glycogen synthase kinase-3 (GSK3) plays important roles in numerous signaling pathways
that regulate a variety of cellular processes including cell proliferation, differentiation …

The p70 ribosomal protein S6 kinase 1 (S6K1) plays a key role in cell growth and
proliferation by regulating insulin sensitivity, metabolism, protein synthesis, and cell cycle …