The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

The transcription factor hepatic leukemia factor (HLF) is strongly expressed in hematopoietic
stem cells (HSCs) and is thought to influence both HSC self-renewal and leukemogenesis …

Cell reprogramming is a revolutionized biotechnology that offers a powerful tool to engineer
cell fate and function for regenerative medicine, disease modeling, drug discovery, and …

H3. 3 is a histone variant, which is deposited on genebodies and regulatory elements, by
Hira, marking active transcription. Moreover, H3. 3 is deposited on heterochromatin by …

The Haematopoietically expressed homeobox transcription factor (Hhex) is a transcriptional
repressor that is of fundamental importance across species, as evident by its evolutionary …

Background Macrophage-based cell therapy is promising in solid tumors, but the efficient
acquisition of macrophages remains a challenge. Induced pluripotent stem cell (iPSC) …

Growth factor independence 1 (GFI1) and the closely related protein GFI1B are small
nuclear proteins that act as DNA binding transcriptional repressors. Both recognize the …

Although lineage reprogramming from one cell type to another is becoming a breakthrough
technology for cell-based therapy, several limitations remain to be overcome, including the …

Cell reprogramming concepts have been classically developed in the fields of
developmental and stem cell biology and are currently being explored for regenerative …