Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to
develop safe and affordable new drugs to counter the spread of malaria parasites that are …

Currently, nearly two billion people are at risk of contracting malaria and the incidence of this
disease is dramatically increasing because many Plasmodium falciparum strains, the …

Approximately 40% of the world population live in areas with the risk of malaria. Each year,
300–500 million people suffer from acute malaria, and 0.5–2.5 million die from the disease …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

This review on the interplay between malaria, antimalarial drugs, and hemozoin crystals is
directed, on one hand, to biologists and pharmaceutical chemists who wish to have a …

Malaria continues to be a potentially fatal threat to almost half of the world's population. In
light of this threat, the armory to fight this disease is rather limited. Resistance against the …

Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has
been used in China for over 30 years for the treatment of malaria. Pyronaridine has high …

Despite the pharmacodynamic advantages with artemisinin-based combination therapy
(ACT) and some potentially opposite molecular mechanisms of tolerance to amodiaquine …

The morphology of micrometer-sized β-hematin crystals (synthetic malaria pigment) was
determined by TEM images and diffraction, and by grazing incidence synchrotron X-ray …

The problem of endemic malaria continues unabated globally. Malaria affects 40% of the
global population, causing an estimated annual mortality of 1.5-2.7 million people. The …