Oxidative stress is implicated in the pathogenesis and progression of Alzheimer's disease
(AD) and its earlier stage, amnestic mild cognitive impairment (aMCI). One source of …

Brain computation is metabolically expensive and requires the supply of significant amounts
of energy. Mitochondria are highly specialized organelles whose main function is to …

As a key contributor to memory storage, the synapse is one of the earliest affected neuronal
components in Alzheimers disease (AD). Under physiological conditions, the synaptic …

After decades of Alzheimer's disease (AD) research, the development of a definitive
diagnostic test for this disease has remained elusive. The discovery of blood-borne …

Brain extracellular matrix (ECM) is a highly organized system that consists of collagens,
noncollagenous proteins, glycoproteins, hyaluronan, and proteoglycans. Recognized …

Neurodegenerative diseases, such as Alzheimer′ s diseases (AD), are becoming more
prevalent as the population ages. However, the mechanisms that lead to synapse …

Tau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the
present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases …

The field of proteomics is undergoing rapid development in a number of different areas
including improvements in mass spectrometric platforms, peptide identification algorithms …

Quantitative proteomics analysis of cortical samples of 10 Alzheimer's disease (AD) brains
versus 10 normally aged brains was performed by following the accurate mass and time tag …

The global burden of Alzheimer's disease (AD) is growing. Valiant efforts to develop clinical
candidates for treatment have continuously met with failure. Currently available palliative …