Epilepsy affects~ 65 million people worldwide. First-line treatment options include> 20
antiseizure medications, but seizure control is not achieved in approximately one-third of …

Neuroinflammation and epilepsy are different pathologies, but, in some cases, they are so
closely related that the activation of one of the pathologies leads to the development of the …

Ammonia has been long recognized as a metabolic waste product with well-known
neurotoxic effects. However, little is known about the beneficial function of endogenous …

Astrocytes are the main homeostatic cells in the central nervous system (CNS) and they
have an essential role in preserving neuronal physiology. After brain injury, astrocytes …

Astrocytes play a dual role in the brain. On the one hand, they are active signaling partners
of neurons and can for instance control synaptic transmission and its plasticity. On the other …

Oxidative stress and apoptosis following seizures play pivotal roles in the consequences of
repeated seizures. Beneficial effects of alpha-pinene (APN) have been reported in some …

Kainic acid (KA), an analogue of the excitatory neurotransmitter glutamate, when
administered systemically can trigger seizures and neuronal loss in a manner that mirrors …

Background Chronic pain is a common, poorly understood condition. Genetic studies
including genome-wide association studies have identified many relevant variants, which …

Epilepsy is a common chronic brain disease. There are many clinical methods to control
epileptic seizures, such as anti-seizure medications (ASMs) or surgical removal of …

To prevent ocular pathologies, new generation of dietary supplements have been
commercially available. They consist of nutritional supplement mixing components known to …