Pulmonary hypertension describes a heterogeneous disease defined by increased
pulmonary artery pressures, and progressive increase in pulmonary vascular resistance due …

Pulmonary arterial hypertension (PAH) is a progressive disease of the lung vasculature that
involves the loss of endothelial function together with inappropriate smooth muscle cell …

Inflammation and immunity play a causal role in the pathogenesis of pulmonary vascular
remodelling and pulmonary arterial hypertension (PAH). However, the pathways and …

Cardiovascular disease (CVD) is one of the leading causes of mortality in humans, and
oxidative stress plays a pivotal role in disease progression. This phenomenon typically …

Pulmonary arterial hypertension (PAH) is a rare yet devastating and incurable disease with
few treatment options. The underlying mechanisms of PAH appear to involve substantial …

Pulmonary hypertension (PH) is a severe and multifactorial disease characterized by a
progressive elevation of pulmonary arterial resistance and pressure due to remodeling …

Pulmonary hypertension (PH) is a cardiopulmonary disease characterized by a progressive
increase in pulmonary vascular resistance. One of the initial pathogenic factors of PH is …

Reactive oxygen species (ROS) exert signaling character (redox signaling), or damaging
character (oxidative stress) on cardiac tissue depending on their concentration and/or …

The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family is the
major source of reactive oxygen species (ROS) in the vascular system. In this family, NOX4 …

Endothelial–mesenchymal transition (EnMT) plays a pivotal role in various diseases,
including pulmonary hypertension (PH), and transcription factors like Snail are key …