Best practices on the differential expression analysis of multi-species RNA-seq
Advances in transcriptome sequencing allow for simultaneous interrogation of differentially
expressed genes from multiple species originating from a single RNA sample, termed dual …
expressed genes from multiple species originating from a single RNA sample, termed dual …
Venn diagram analysis overestimates the extent of circadian rhythm reprogramming
The circadian clock modulates key physiological processes in many organisms. This
widespread role of circadian rhythms is typically characterized at the molecular level by …
widespread role of circadian rhythms is typically characterized at the molecular level by …
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program
Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic
lymphocytic choriomeningitis virus infection. Here we examine the underlying basis for this …
lymphocytic choriomeningitis virus infection. Here we examine the underlying basis for this …
ApoE isoform–and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy
Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease. Primary tauopathies
are characterized by pathological tau accumulation and neuronal and synaptic loss …
are characterized by pathological tau accumulation and neuronal and synaptic loss …
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease
As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal
immune cells of this organ. Microglial features are strongly dependent on environmental …
immune cells of this organ. Microglial features are strongly dependent on environmental …
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function
Although animal models have been evaluated for severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease …
coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease …
[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2
DJ Jackson, WW Busse, LB Bacharier… - Journal of Allergy and …, 2020 - jacionline.org
SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as its cellular receptor, as do
SARS-CoV and the coronavirus NL63. 1 Higher ACE2 expression increases in vitro …
SARS-CoV and the coronavirus NL63. 1 Higher ACE2 expression increases in vitro …
Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH
S Daemen, A Gainullina, G Kalugotla, L He, MM Chan… - Cell reports, 2021 - cell.com
Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic
steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding …
steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding …
[HTML][HTML] Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity
Recent studies suggest that mitochondria can be transferred between cells to support the
survival of metabolically compromised cells. However, whether intercellular mitochondria …
survival of metabolically compromised cells. However, whether intercellular mitochondria …