Systemic lupus erythematosus pathogenesis: interferon and beyond
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
Type I interferon–related kidney disorders
L Lodi, MV Mastrolia, F Bello, GM Rossi, ML Angelotti… - Kidney international, 2022 - Elsevier
Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly
affecting the biology and function of several renal cell types including podocytes, mesangial …
affecting the biology and function of several renal cell types including podocytes, mesangial …
[HTML][HTML] Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus
J Hartl, L Serpas, Y Wang, A Rashidfarrokhi… - Journal of Experimental …, 2021 - rupress.org
Disclosures: P. Izmirly reported personal fees from GlaxoSmithKline outside the submitted
work. JP Buyon reported personal fees from Bristol-Myers Squibb LN advisory board …
work. JP Buyon reported personal fees from Bristol-Myers Squibb LN advisory board …
Systemic lupus erythematosus as a genetic disease
ITW Harley, AH Sawalha - Clinical Immunology, 2022 - Elsevier
Systemic lupus erythematosus is the prototypical systemic autoimmune disease, as it is
characterized both by protean multi-organ system manifestations and by the uniform …
characterized both by protean multi-organ system manifestations and by the uniform …
Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease
Histone deacetylases (HDACs) catalyse removal of acetyl groups from lysine residues on
both histone and non‐histone proteins to control numerous cellular processes. Of the 11 …
both histone and non‐histone proteins to control numerous cellular processes. Of the 11 …
Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2
Histone deacetylases (HDACs) drive innate immune cell-mediated inflammation. Here we
identify class IIa HDACs as key molecular links between Toll-like receptor (TLR)-inducible …
identify class IIa HDACs as key molecular links between Toll-like receptor (TLR)-inducible …
[HTML][HTML] Plasma DNA profile associated with DNASE1L3 gene mutations: clinical observations, relationships to nuclease substrate preference, and in vivo correction
Plasma DNA fragmentomics is an emerging area in cell-free DNA diagnostics and research.
In murine models, it has been shown that the extracellular DNase, DNASE1L3, plays a role …
In murine models, it has been shown that the extracellular DNase, DNASE1L3, plays a role …
Glycolysis in innate immune cells contributes to autoimmunity
Y Xu, Y Chen, X Zhang, J Ma, Y Liu, L Cui… - Frontiers in …, 2022 - frontiersin.org
Autoimmune diseases (AIDs) refer to connective tissue inflammation caused by aberrant
autoantibodies resulting from dysfunctional immune surveillance. Most of the current …
autoantibodies resulting from dysfunctional immune surveillance. Most of the current …
Systemic lupus erythematosus–are children miniature adults?
T Alexander, CM Hedrich - Clinical Immunology, 2022 - Elsevier
Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease that
can affect any organ system and cause significant damage and organ failure. Disease-onset …
can affect any organ system and cause significant damage and organ failure. Disease-onset …
Novel loss-of-function mutations in TNFAIP3 gene in patients with lupus nephritis
C Zhang, X Han, L Sun, S Yang, J Peng… - Clinical Kidney …, 2022 - academic.oup.com
Background Heterozygous loss-of-function mutations in the tumour necrosis factor alpha
induced protein 3 (TNFAIP3) gene cause an early-onset auto-inflammatory disease named …
induced protein 3 (TNFAIP3) gene cause an early-onset auto-inflammatory disease named …