The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

Sleep is thought to be restorative to brain energy homeostasis, but it is not clear how this is
achieved. We show here that Drosophila glia exhibit a daily cycle of glial mitochondrial …

Sleep is a biological enigma that has raised numerous questions about the inner workings
of the brain. The fundamental question of why our nervous systems have evolved to require …

Employing the clear, student-friendly style that made previous editions so popular, Insect
Physiology and Biochemistry, Fourth Edition presents an engaging and authoritative guide …

Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of
the mechanisms involved have focused largely on acute sleep deprivation. 1, 2 To identify …

Sleep is essential for proper brain function in mammals and insects. During sleep, animals
are disconnected from the external world; they show high arousal thresholds and changed …

Individuals vary extensively in the way they respond to disease but the genetic basis of this
variation is not fully understood. We found substantial individual variation in resistance and …

Severe sleep deprivation (SD) has been highly associated with systemic energy wasting,
such as lipid loss and glycogen depletion. Despite immune dysregulation and neurotoxicity …

Why do some individuals need more sleep than others? Forward mutagenesis screens in
flies using engineered mutations have established a clear genetic component to sleep …

Sleep behavior is conserved throughout evolution, and sleep disturbances are a frequent
comorbidity of neuropsychiatric disorders. However, the molecular basis underlying sleep …