[HTML][HTML] Mitochondrial control of inflammation
Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …
associated molecular patterns (DAMPs) and promote inflammation when released into the …
[HTML][HTML] Mitochondria and cell death-associated inflammation
E Vringer, SWG Tait - Cell Death & Differentiation, 2023 - nature.com
Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …
death. Many of the pro-inflammatory pathways activated during cell death occur upon …
[HTML][HTML] Apoptotic stress causes mtDNA release during senescence and drives the SASP
Senescent cells drive age-related tissue dysfunction partially through the induction of a
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …
Targeting immunogenic cell death in cancer
A Ahmed, SWG Tait - Molecular oncology, 2020 - Wiley Online Library
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic …
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic …
[HTML][HTML] Programmed cell death tunes tumor immunity
The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …
the years revealed distinctive molecular mechanisms and functional consequences of …
Targeting apoptosis in cancer therapy
BA Carneiro, WS El-Deiry - Nature reviews Clinical oncology, 2020 - nature.com
For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
[HTML][HTML] The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
K Cosentino, V Hertlein, A Jenner, T Dellmann… - Molecular cell, 2022 - cell.com
BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial
outer membrane permeabilization. However, the mechanism by which they assemble the …
outer membrane permeabilization. However, the mechanism by which they assemble the …
Mitochondria as multifaceted regulators of cell death
Through their many and varied metabolic functions, mitochondria power life. Paradoxically,
mitochondria also have a central role in apoptotic cell death. Upon induction of …
mitochondria also have a central role in apoptotic cell death. Upon induction of …
Modes of regulated cell death in cancer
E Koren, Y Fuchs - Cancer discovery, 2021 - AACR
Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …
Mitochondrial DNA in inflammation and immunity
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …
from energy production and metabolism to cell death and inflammation. Despite this …