Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …

Senescent cells drive age-related tissue dysfunction partially through the induction of a
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …

Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic …

The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial
outer membrane permeabilization. However, the mechanism by which they assemble the …

Through their many and varied metabolic functions, mitochondria power life. Paradoxically,
mitochondria also have a central role in apoptotic cell death. Upon induction of …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …