Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance
Interactions between cancer cells and their surroundings can trigger essential signaling
cues that determine cell fate and influence the evolution of the malignant phenotype. As the …
cues that determine cell fate and influence the evolution of the malignant phenotype. As the …
Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy
H Hua, Q Kong, J Yin, J Zhang, Y Jiang - Journal of hematology & …, 2020 - Springer
Insulin-like growth factors (IGFs) play important roles in mammalian growth, development,
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …
Can we unlock the potential of IGF-1R inhibition in cancer therapy?
H King, T Aleksic, P Haluska, VM Macaulay - Cancer treatment reviews, 2014 - Elsevier
IGF-1R inhibitors arrived in the clinic accompanied by optimism based on preclinical activity
of IGF-1R targeting, and recognition that low IGF bioactivity protects from cancer. This was …
of IGF-1R targeting, and recognition that low IGF bioactivity protects from cancer. This was …
IGF2 signaling and regulation in cancer
J Brouwer-Visser, GS Huang - Cytokine & growth factor reviews, 2015 - Elsevier
Upregulation of IGF2 occurs in both childhood and adult malignancies. Its overexpresssion
is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is …
is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is …
Role of integrins in resistance to therapies targeting growth factor receptors in cancer
E Cruz da Silva, M Dontenwill, L Choulier, M Lehmann - Cancers, 2019 - mdpi.com
Integrins contribute to cancer progression and aggressiveness by activating intracellular
signal transduction pathways and transducing mechanical tension forces. Remarkably …
signal transduction pathways and transducing mechanical tension forces. Remarkably …
Simultaneous β1 integrin-EGFR targeting and radiosensitization of human head and neck cancer
I Eke, K Zscheppang, E Dickreuter… - Journal of the …, 2015 - academic.oup.com
Background: Signaling from integrins and receptor tyrosine kinases (RTKs) contributes
substantially to therapy resistance of malignant tumors. We investigated simultaneous β1 …
substantially to therapy resistance of malignant tumors. We investigated simultaneous β1 …
Recent advances of small-molecule c-Src inhibitors for potential therapeutic utilities
XW Dang, JL Duan, E Ye, ND Mao, RR Bai, X Zhou… - Bioorganic …, 2024 - Elsevier
Proto-oncogene tyrosine-protein kinase Src, also known as c-Src, belongs to the family of
non-receptor tyrosine protein kinases (TKs) called Src kinases. It plays a crucial role in cell …
non-receptor tyrosine protein kinases (TKs) called Src kinases. It plays a crucial role in cell …
[HTML][HTML] Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer
JY Ahn, JS Lee, HY Min, HY Lee - Oncotarget, 2015 - ncbi.nlm.nih.gov
fluorouracil (5-FU), one of the first-line chemotherapeutic agents for the treatment of
gastrointestinal malignancies, has shown limited efficacy. The expression of thymidylate …
gastrointestinal malignancies, has shown limited efficacy. The expression of thymidylate …
Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
Y Zhang, H Qian, J He, W Gao - Biomarker research, 2020 - Springer
The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered
noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre …
noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre …
IGF-1R and mTOR blockade: novel resistance mechanisms and synergistic drug combinations for Ewing sarcoma
SE Lamhamedi-Cherradi, BA Menegaz… - JNCI: Journal of the …, 2016 - academic.oup.com
Background: Therapies cotargeting insulin-like growth factor receptor 1 (IGF-1R) and
mammalian target of rapamycin (mTOR) have demonstrated remarkable, albeit short-lived …
mammalian target of rapamycin (mTOR) have demonstrated remarkable, albeit short-lived …