Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), is the current
leading cause of death due to a single infectious organism. Although curable, the broad …

Glycosylation of proteins is one of the most prevalent post-translational modifications
occurring in nature, with a wide repertoire of biological implications. Pathways for the main …

To effectively modulate the gene expression within an infected mammalian cell, the
pathogen Mycobacterium tuberculosis would need to bring about epigenetic modifications at …

Multiple regulatory mechanisms including post-translational modifications (PTMs) confer
complexity to the simpler genomes and proteomes of Mycobacterium tuberculosis (Mtb) …

TLR2-dependent cellular signaling in Mycobacterium tuberculosis-infected macrophages
causes apoptosis and inhibits class II major histocompatibility complex (MHC-II) molecules …

Cyclic GMP-AMP synthase (cGAS) is an important cytosolic DNA sensor that plays a crucial
role in triggering STING-dependent signal and inducing type I interferons (IFNs). cGAS is …

A better understanding of the kinetics of accumulated immune cells that are involved in
pathophysiology during Mycobacterium tuberculosis (Mtb) infection may help to facilitate the …

Highlights•Many viruses inhibit MHC-II presentation by targeting host defense signaling
pathways.•Some viruses target specific components of the MHC-II presentation …

Heterologous prime–boosting has emerged as a powerful vaccination approach against
tuberculosis. However, optimal timing to boost BCG-immunity using subunit vaccines …

Lactoferrin (LF), an iron binding protein with immune modulatory activities, has adjuvant
activity to enhance vaccine efficacy. Tuberculosis (TB) is a pulmonary disease caused by the …