The exocyst at a glance

B Wu, W Guo - Journal of cell science, 2015 - journals.biologists.com
The exocyst is an octameric protein complex that is implicated in the tethering of secretory
vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal …

The exocyst complex in health and disease

M Martin-Urdiroz, MJ Deeks, CG Horton… - Frontiers in Cell and …, 2016 - frontiersin.org
Exocytosis involves the fusion of intracellular secretory vesicles with the plasma membrane,
thereby delivering integral membrane proteins to the cell surface and releasing material into …

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

JR Cerhan, SI Berndt, J Vijai, H Ghesquières… - Nature …, 2014 - nature.com
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is
clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta …

Tunneling nanotubes and related structures: molecular mechanisms of formation and function

S Dagar, D Pathak, HV Oza… - Biochemical …, 2021 - portlandpress.com
Tunneling nanotubes (TNTs) are F-actin-based, membrane-enclosed tubular connections
between animal cells that transport a variety of cellular cargo. Over the last 15 years since …

Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency

L Wang, S Tsutsumi, T Kawaguchi, K Nagasaki… - Genome …, 2012 - genome.cshlp.org
Whole-exome sequencing (Exome-seq) has been successfully applied in several recent
studies. We here sequenced the exomes of 15 pancreatic tumor cell lines and their matched …

MicroRNA‐99 family in cancer and immunity

J Eniafe, S Jiang - Wiley Interdisciplinary Reviews: RNA, 2021 - Wiley Online Library
Abstract The microRNA (miR)‐99 family comprising miR‐99a, miR‐99b, and miR‐100 is an
evolutionarily conserved family with existence dating prior to the bilaterians. Members are …

MicroRNA-99a suppresses breast cancer progression by targeting FGFR3

X Long, Y Shi, P Ye, J Guo, Q Zhou, Y Tang - Frontiers in oncology, 2020 - frontiersin.org
MicroRNAs have been implicated in acting as oncogenes or anti-oncogenes in breast
cancer by regulating diverse cellular pathways. In the present study, we investigated the …

Ral GTPases: crucial mediators of exocytosis and tumourigenesis

R Shirakawa, H Horiuchi - The journal of biochemistry, 2015 - academic.oup.com
Abstract The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the
Ras superfamily of small GTPases. Research on Ral GTPases and their functions over the …

Rabs and the exocyst in ciliogenesis, tubulogenesis and beyond

A Das, W Guo - Trends in cell biology, 2011 - cell.com
The exocyst, an octameric protein complex mediating vesicle tethering at the plasma
membrane for exocytosis, is a downstream effector of the Rab proteins Rab8 and Rab11 …

Ral signaling pathway in health and cancer

AR Moghadam, E Patrad, E Tafsiri, W Peng… - Cancer …, 2017 - Wiley Online Library
Abstract The Ral (Ras‐Like) signaling pathway plays an important role in the biology of
cells. A plethora of effects is regulated by this signaling pathway and its prooncogenic …